Evidence map›Paper›PMID 22349159›Full record

ArticleEuropean journal of clinical pharmacology2012

Inappropriate prescribing for the elderly--a modern epidemic?

Gunhild Nyborg, Jørund Straand, Mette Brekke

Abstract read
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In one paragraph

Article in European journal of clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Reducing potentially inappropriate medications in palliative cancer patients: evidence to support deprescribing approaches.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Pooled it
  8. Trial
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  10. Prescription peer academic detailing to reduce inappropriate prescribing for older patients: a cluster randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2013
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  11. Article
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  16. Patient harm from cardiovascular medications.Therapeutic advances in drug safety · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gunhild NyborgDepartment of General Practice/Family Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway. gunhild.nyborg@medisin.uio.no
Jørund Straand
Mette Brekke

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe elderly often use several drugs on a regular basis and are especially at risk for drug-related harm from side effects and interactions. The aim of this study was to explore the overall prevalence of and predictors for potentially inappropriate medication use among Norwegian elderly outpatients.

methodsA pharmaco-epidemiological retrospective cross-sectional survey was undertaken based on data from the Norwegian Prescription Database. Prescriptions from all doctors in Norway, dispensed by pharmacies to home-dwelling elderly ≥ 70 years in 2008, were included for a total of 11,491,065 prescriptions from 24,540 prescribers to 445,900 individuals (88.3% of the Norwegian population in this age group, 58.9% females). We applied a list of criteria for pharmacological inappropriateness for elderly people (the NORGEP criteria) to determine the prevalence of potentially inappropriate medications (PIMs) and applied a multiple logistic regression model to identify predictors.

resultsAccording to our criteria, 34.8% of the study population (28.5% of the men, 39.3% of the women) was exposed to at least one PIM. Of these, 59.9% represented psychoactive substances. The odds of receiving potentially harmful prescriptions increased with the number of prescribers (OR 3.52, 99% CI 3.44-3.60 for those with ≥ 5 compared to those with 1 or 2 prescribers). Twenty percent were prescribed more than 10 medications; among these two-thirds had at least one PIM. Adjusted for differences in age distribution and the number of prescribers involved, women were more frequently exposed to PIMs than men, with an odds ratio of 1.60 (99% CI 1.58-1.64).

conclusionsAbout one-third of the elderly Norwegian population is exposed to potentially inappropriate medications, and elderly females are at particular risk.

Indexed as

Pharmaceutical PreparationsPharmacoepidemiologyAgedAged, 80 and overCross-Sectional StudiesDatabases, FactualData Interpretation, StatisticalDrug InteractionsDrug PrescriptionsDrug-Related Side Effects and Adverse ReactionsFemaleHumansInappropriate PrescribingMaleNorwayOutpatientsPharmaceutical Preparations

Identifiers

PMID22349159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.