Evidence map›Paper›PMID 22349141›Full record

ReviewCurrent opinion in genetics & development2012

Small RNA in the nucleus: the RNA-chromatin ping-pong.

Ivan Olovnikov, Alexei A Aravin, Katalin Fejes Toth

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. New players on the piRNA field.Nature structural & molecular biology · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Defining functional DNA elements in the human genome.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Ivan OlovnikovCalifornia Institute of Technology, Division of Biology, Pasadena, CA 91125, USA.
Alexei A Aravin
Katalin Fejes Toth
California Institute of Technology · US

Funding

Molecular Mechanism of the piRNA BiogenesisR01GM097363 · NIGMS · CORNELL UNIVERSITY · PI ARAVIN, ALEXEI A. · 2011 to 2025
$4.0M
Taming of Small RNA-based Epigenetic MechanismsDP2OD007371 · OD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ARAVIN, ALEXEI A. · 2010 to 2010
$2.4M
Functions of Piwi proteins and short RNAs in germlineR00HD057233 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ARAVIN, ALEXEI A. · 2010 to 2012
$738k
NICHD NIH HHS R00 HD057233NIGMS NIH HHS R01 GM097363NIH HHS DP2 OD007371NIH HHS DP2 OD007371A
6 · The paper itself

Abstract

Eukaryotes use several classes of small RNA molecules to guide diverse protein machineries to target messenger RNA. The role of small RNA in post-transcriptional regulation of mRNA stability and translation is now well established. Small RNAs can also guide sequence-specific modification of chromatin structure and thus contribute to establishment and maintenance of distinct chromatin domains. In this review we summarize the model for the inter-dependent interaction between small RNA and chromatin that has emerged from studies on fission yeast and plants. We focus on recent results that link a distinct class of small RNAs, the piRNAs, to chromatin regulation in animals.

Indexed as

AnimalsCell NucleusChromatinGene Expression RegulationHumansRNA, Small InterferingTranscription, GeneticChromatinRNA, Small Interfering

Identifiers

PMID22349141
PMCPMC3345048
OpenAlexW1984301208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.