ArticleDiabetologia2012
Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.The Journal of clinical endocrinology and metabolism · 2021Pooled it
- Genetic determinants of circulating GIP and GLP-1 concentrations.JCI insight · 2017Pooled it
- Glycemic Benefit of Insulin Degludec/Insulin Aspart Compared to Basal Insulin in Type 2 Diabetes Mellitus Associated with Impaired Glucagon-Like Peptide-1 Response: A Randomized Crossover Trial.Diabetes & metabolism journal · 2026Trial
- Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk.Pediatric research · 2024Trial
- Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists.Genome medicine · 2026Article
- Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists.Frontiers in endocrinology · 2024Review
- Relation of Aortic Waveforms with Gut Hormones following Continuous and Interval Exercise among Older Adults with Prediabetes.Metabolites · 2023Article
- Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Repositioning the Alpha Cell in Postprandial Metabolism.Endocrinology · 2020Review
- Article
- An impaired glucagon-like peptide-1 response is associated with prediabetes in polycystic ovary syndrome with obesity.The Journal of international medical research · 2019Article
- Characterisation of Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonists in Rodent Pancreatic Beta Cells and Mice.Clinical medicine insights. Endocrinology and diabetes · 2019Article
- Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study.BMC medical genetics · 2018Article
- Shared Genetic Control of Brain Activity During Sleep and Insulin Secretion: A Laboratory-Based Family Study.Diabetes · 2018Article
- Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk.Endocrine · 2017Article
- Genetic and phenotypic correlations between surrogate measures of insulin release obtained from OGTT data.Diabetologia · 2015Article
- Article
- The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes.PloS one · 2015Article
- Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis.PloS one · 2014Article
- Genetics of Type 2 Diabetes: It Matters From Which Parent We Inherit the Risk.The review of diabetic studies : RDSReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisHeritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin, serum C-peptide, plasma glucose-dependent insulinotropic polypeptide (GIP) and plasma glucagon-like peptide-1 (GLP-1) among non-diabetic relatives of Danish type 2 diabetic patients.
methodsSixty-one families comprising 193 non-diabetic offspring, 29 non-diabetic spouses, 72 non-diabetic relatives (parent, sibling, etc.) and two non-related relatives underwent a 4 h 75 g OGTT with measurements of plasma glucose, serum insulin, serum C-peptide, plasma GIP and plasma GLP-1 levels at 18 time points. Insulin secretion rates (ISR) and beta cell responses to glucose, GIP and GLP-1 were calculated. Familiality was estimated based on OGTT-derived measures.
resultsA high level of familiality was observed during the OGTT for plasma levels of GIP and GLP-1, with peak familiality values of 74 ± 16% and 65 ± 15%, respectively (h (2) ± SE). Familiality values were lower for plasma glucose, serum insulin and serum C-peptide during the OGTT (range 8-48%, 14-44% and 15-61%, respectively). ISR presented the highest familiality value at fasting reaching 59 ± 16%. Beta cell responsiveness to glucose, GLP-1 and GIP also revealed a strong genetic influence, with peak familiality estimates of 62 ± 13%, 76 ± 15% and 70 ± 14%, respectively. CONCLUSIONS/
interpretationOur results suggest that circulating levels of GIP and GLP-1 as well as beta cell response to these incretins are highly familial compared with more commonly investigated measures of glucose homeostasis such as fasting and stimulated plasma glucose, serum insulin and serum C-peptide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.