ArticleNitric oxide : biology and chemistry2012
Examination of bacterial resistance to exogenous nitric oxide.
Article in Nitric oxide : biology and chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
82 citing papers in PubMed.
- Novel Nitric Oxide-Releasing Formulations Show Fungicidal Potential for Superficial Dermatophyte Infection.Journal of fungi (Basel, Switzerland) · 2026Article
- Nitric oxide-releasing hyaluronic acid as an antibacterial and immunomodulatory acne therapeutic.RSC advances · 2026Article
- Nitric Oxide-Releasing Gels in the Context of Antimicrobial Stewardship, Biofilm Management, and Wound-Repair Biology.Antibiotics (Basel, Switzerland) · 2026Review
- Potential of Nitric Oxide and Bacteriophages as Combined Antibacterial Agents to Counter Drug-Resistant Infections.ACS applied bio materials · 2025Article
- Penetration and Preliminary Efficacy of a Novel Nitric Oxide-Releasing Gel for Onychomycosis.Journal of fungi (Basel, Switzerland) · 2025Article
- Article
- Wound healing properties and antibiofilm activity of hydrogel matrix containing nitric oxide, silver nanoparticles, and ciprofloxacin against Pseudomonas aeruginosa burn wound infection.Scientific reports · 2025Article
- Combating Concomitant Bacterial and Fungal Infections via Codelivery of Nitric Oxide and Fluconazole.ACS applied materials & interfaces · 2025Article
- Nitric Oxide Inhibition of Glycyl Radical Enzymes and Their Activases.Journal of the American Chemical Society · 2025Article
- Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing.Journal of nanobiotechnology · 2025Review
- Assessing the role of exogenous NO on plants and microbial communities in soil.ISME communications · 2025Article
- Enhanced Nitric Oxide Delivery Through Self-Assembling Nanoparticles for Eradicating Gram-Negative Bacteria.Advanced healthcare materials · 2024Article
- Nanoparticle-Based Nitric Oxide Donors: Exploring Their Antimicrobial and Anti-Biofilm Capabilities.Antibiotics (Basel, Switzerland) · 2024Review
- Delivery of Nitric Oxide by Chondroitin Sulfate C Increases the Rate of Wound Healing through Immune Modulation.ACS applied bio materials · 2024Article
- Analysis of the broad-spectrum potential of nitric oxide for antibacterial activity against clinically isolated drug-resistant bacteria.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Engineering Nitric Oxide-Releasing Antimicrobial Dental Coating for Targeted Gingival Therapy.ACS applied bio materials · 2024Article
- Article
- Copper-Cystine Biohybrid-Embedded Nanofiber Aerogels Show Antibacterial and Angiogenic Properties.ACS omega · 2024Article
- Nitric oxide-releasing prodrug for the treatment of complexAntimicrobial agents and chemotherapy · 2024Article
- Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
While much research has been directed to harnessing the antimicrobial properties of exogenous NO, the possibility of bacteria developing resistance to such therapy has not been thoroughly studied. Herein, we evaluate potential NO resistance using spontaneous and serial passage mutagenesis assays. Specifically, Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa were systematically exposed to NO-releasing 75mol% MPTMS-TEOS nitrosothiol particles at or below minimum inhibitory concentration (MIC) levels. In the spontaneous mutagenesis assay, bacteria that survived exposure to lethal concentrations of NO showed no increase in MIC. Similarly, no increase in MIC was observed in the serial passage mutagenesis assay after exposure of these species to sub-inhibitory concentrations of NO through 20 d.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.