ReviewBiochimica et biophysica acta2012
Protein degradation and iron homeostasis.
Review in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Iron Metabolism and Inflammatory Mediators in Patients with Renal Dysfunction.International journal of molecular sciences · 2024Review
- Comparison of oral iron chelators in the management of transfusion-dependent β-thalassemia major based on serum ferritin and liver enzymes.F1000Research · 2023Article
- Iron homeostasis and organismal aging.Ageing research reviews · 2021Review
- Lipopolysaccharide reduces USP13 stability through c-Jun N-terminal kinase activation in Kupffer cells.Journal of cellular physiology · 2021Article
- FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.Molecular cell · 2020Article
- Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology.Frontiers in oncology · 2020Review
- Dissecting mRNA decay and translation inhibition during iron deficiency.Current genetics · 2019Review
- Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review.Frontiers in physiology · 2019Review
- The Role of Iron and Iron Overload in Chronic Liver Disease.Medical science monitor : international medical journal of experimental and clinical research · 2016Review
- Involvement of Iron-Containing Proteins in Genome Integrity in Arabidopsis Thaliana.Genome integrity · 2015Review
- Intracellular iron sensing by the direct binding of iron to regulators.Frontiers in plant science · 2015Article
- HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.The Journal of biological chemistry · 2014Article
- F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.Journal of inorganic biochemistry · 2014Review
- Long non-coding RNA and alternative splicing modulations in Parkinson's leukocytes identified by RNA sequencing.PLoS computational biology · 2014Article
- The role of mitochondria in cellular iron-sulfur protein biogenesis: mechanisms, connected processes, and diseases.Cold Spring Harbor perspectives in biology · 2013Review
- Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C.BMC medical genomics · 2013Article
- F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.The Journal of biological chemistry · 2013Article
- Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.PLoS pathogens · 2013Article
- Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis.Biochemistry · 2012Review
- Serum aflatoxin B1 antibody titer, percent hemolysis and transaminases in oral submucous fibrosis.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Regulation of both systemic and cellular iron homeostasis requires the capacity to sense iron levels and appropriately modify the expression of iron metabolism genes. These responses are coordinated through the efforts of several key regulatory factors including F-box and Leucine-rich Repeat Protein 5 (FBXL5), Iron Regulatory Proteins (IRPs), Hypoxia Inducible Factor (HIF), and ferroportin. Notably, the stability of each of these proteins is regulated in response to iron. Recent discoveries have greatly advanced our understanding of the molecular mechanisms governing iron-sensing and protein degradation within these pathways. It has become clear that iron's privileged roles in both enzyme catalysis and protein structure contribute to its regulation of protein stability. Moreover, these multiple pathways intersect with one another in larger regulatory networks to maintain iron homeostasis. This article is part of a Special Issue entitled: Cell Biology of Metals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.