ArticleGenome biology2012
Autosomal monoallelic expression in the mouse.
Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk alleles of genes with monoallelic expression are enriched in gain-of-function variants and depleted in loss-of-function variants for neurodevelopmental disorders.Molecular psychiatry · 2017Pooled it
- Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity.eLife · 2026Article
- Beyond genes and environment: mapping biological stochasticity in aging.GeroScience · 2025Review
- Article
- Detection of allele-specific expression in spatial transcriptomics with spASE.Genome biology · 2024Article
- Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale.Bioinformatics (Oxford, England) · 2023Article
- Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale.bioRxiv : the preprint server for biology · 2023Article
- Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage.Nature communications · 2022Article
- RNA sequencing-based screen for reactivation of silenced alleles of autosomal genes.G3 (Bethesda, Md.) · 2022Article
- Article
- Identification of Monoallelically Expressed Genes Associated with Economic Traits in Hanwoo (Korean Native Cattle).Animals : an open access journal from MDPI · 2021Article
- The good, the bad, and the ugly: Evolutionary and pathological aspects of gene dosage alterations.PLoS genetics · 2021Review
- Introns control stochastic allele expression bias.Nature communications · 2021Article
- Semicoordinated allelic-bursting shape dynamic random monoallelic expression in pregastrulation embryos.iScience · 2021Article
- Locus specific epigenetic modalities of random allelic expression imbalance.Nature communications · 2021Article
- Replicate sequencing libraries are important for quantification of allelic imbalance.Nature communications · 2021Article
- Parental bias in expression and interaction of genes in the equine placenta.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genome-wide analysis of allele-specific expression of genes in the model diatom Phaeodactylum tricornutum.Scientific reports · 2021Article
- A Comprehensive Characterization of Monoallelic Expression During Hematopoiesis and LeukemogenesisFrontiers in cell and developmental biology · 2021Article
- X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as "Faux Amis".Frontiers in cell and developmental biology · 2021Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRandom monoallelic expression defines an unusual class of genes displaying random choice for expression between the maternal and paternal alleles. Once established, the allele-specific expression pattern is stably maintained and mitotically inherited. Examples of random monoallelic genes include those found on the X-chromosome and a subset of autosomal genes, which have been most extensively studied in humans. Here, we report a genome-wide analysis of random monoallelic expression in the mouse. We used high density mouse genome polymorphism mapping arrays to assess allele-specific expression in clonal cell lines derived from heterozygous mouse strains.
resultsOver 1,300 autosomal genes were assessed for allele-specific expression, and greater than 10% of them showed random monoallelic expression. When comparing mouse and human, the number of autosomal orthologs demonstrating random monoallelic expression in both organisms was greater than would be expected by chance. Random monoallelic expression on the mouse autosomes is broadly similar to that in human cells: it is widespread throughout the genome, lacks chromosome-wide coordination, and varies between cell types. However, for some mouse genes, there appears to be skewing, in some ways resembling skewed X-inactivation, wherein one allele is more frequently active.
conclusionsThese data suggest that autosomal random monoallelic expression was present at least as far back as the last common ancestor of rodents and primates. Random monoallelic expression can lead to phenotypic variation beyond the phenotypic variation dictated by genotypic variation. Thus, it is important to take into account random monoallelic expression when examining genotype-phenotype correlation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.