Evidence map›Paper›PMID 22348251›Full record

ReviewRadiation research2012

Oxidative stress imaging in live animals with techniques based on electron paramagnetic resonance.

Martyna Elas, Kazuhiro Ichikawa, Howard J Halpern

Abstract readReview
In one paragraph

Review in Radiation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Modular imaging system: Rapid scan EPR at 800 MHz.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Imaging of nitroxides at 250MHz using rapid-scan electron paramagnetic resonance.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014
    Article
  13. Electron spin-lattice relaxation mechanisms of rapidly-tumbling nitroxide radicals.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013
    Article
  14. The world as viewed by and with unpaired electrons.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Martyna ElasDepartment of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.
Kazuhiro Ichikawa
Howard J Halpern

Funding

Very Low Frequency EPR Imaging in Vivo Phisiology P41 EB02034P41EB002034 · NIBIB · UNIVERSITY OF CHICAGO · PI HALPERN, HOWARD J · 2003 to 2017
$16.1M
Radiation Biology of EPR Oxygen ImagesR01CA098575 · NCI · UNIVERSITY OF CHICAGO · PI HALPERN, HOWARD J · 2003 to 2022
$4.5M
NCI NIH HHS R01 CA098575NIBIB NIH HHS P41 EB002034
6 · The paper itself

Abstract

Oxidative stress has been the object of considerable biological and biochemical investigation. Quantification has been difficult although the quantitative level of products of biological oxidations in tissues and tissue products has emerged as a widely used technique. The relationship between these products and the amount of oxidative stress is less clear. Imaging oxidative stress with electron paramagnetic resonance related magnetic resonance imaging, while not addressing the specific issue of quantification of initiating events, focuses on the anatomic specific location of the oxidative stress. Moreover, the relative quantification of oxidative stress of one location against another is possible, sharpening our understanding of oxidative stress. This promises to improve our understanding of oxidative stress and its deleterious consequences and enhance our understanding of the effectiveness of interventions to modulate oxidative stress and its consequences.

Indexed as

Oxidative StressAnimalsBrain ChemistryContrast MediaElectron Spin Resonance SpectroscopyFree Radical ScavengersHydroxylamineMagnetic Resonance ImagingMolecular ImagingNeoplasms, ExperimentalNitrogen OxidesNuclear Magnetic Resonance, BiomolecularOxidation-ReductionRadiation-Protective AgentsRatsReactive Oxygen SpeciesContrast MediaFree Radical ScavengersHydroxylamineNitrogen OxidesnitroxylRadiation-Protective AgentsReactive Oxygen SpeciesSpin Labels

Identifiers

PMID22348251
PMCPMC3708477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.