Evidence map›Paper›PMID 22348248›Full record

ReviewRadiation research2012

Imaging molecular pathways: reporter genes.

John Brogan, Fang Li, Wenrong Li, Zhimin He, Qian Huang, Chuan-Yuan Li

Abstract readReview
In one paragraph

Review in Radiation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. In vivo imaging of therapy-induced anti-cancer immune responses in humans.Cellular and molecular life sciences : CMLS · 2013
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

John BroganDepartment of Dermatology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Fang Li
Wenrong Li
Zhimin He
Qian Huang
Chuan-Yuan Li
Duke University Hospital · USDuke Medical Center · US

Funding

The "Phoenix Rising" pathway of tumor repopulation during radiotherapyR01CA155270 · NCI · DUKE UNIVERSITY · PI LI, CHUAN-YUAN · 2011 to 2015
$1.6M
Molecular mechanisms of tumor response to cytotoxic chemotherapyR01CA136748 · NCI · UNIVERSITY OF COLORADO DENVER · PI LI, CHUAN-YUAN · 2009 to 2014
$1.5M
HIF genes in head and neck cancer radiotherapyR01CA131408 · NCI · UNIVERSITY OF COLORADO DENVER · PI LI, CHUAN-YUAN · 2009 to 2014
$1.5M
NCI NIH HHS CA131408NCI NIH HHS CA136748NCI NIH HHS CA155270NCI NIH HHS R01 CA131408NCI NIH HHS R01 CA136748NCI NIH HHS R01 CA155270
6 · The paper itself

Abstract

Molecular imaging is a rapidly advancing field that allows cancer biologists to look deeper into the complex inner workings of tumor cells, or whole tumors, in a non-invasive manner. In this review, we will summarize some recent advances that enable investigators to study various important biological processes in tumors in vivo. We will discuss novel imaging approaches that allow investigators to visualize and quantify molecular pathways, such as receptor tyrosine kinase activation, hypoxia signal transduction, apoptosis, and DNA double-strand breaks. Select examples of these applications will be discussed. Because of the limited scope of this review, we will only focus on natural reporters, such as bioluminescence and fluorescent proteins.

Indexed as

Genes, ReporterAdenosine TriphosphateAnimalsApoptosisCell HypoxiaDNADNA Breaks, Double-StrandedDNA RepairEnzyme ActivationFluorescent DyesGreen Fluorescent ProteinsHumansHypoxia-Inducible Factor 1, alpha SubunitLuciferases, FireflyLuminescent MeasurementsLuminescent ProteinsAdenosine TriphosphateDNAFluorescent DyesGreen Fluorescent ProteinsHypoxia-Inducible Factor 1, alpha Subunitluciferase, PhotinusLuciferases, FireflyLuminescent ProteinsNeoplasm ProteinsOxygenProteasome Endopeptidase ComplexReceptor Protein-Tyrosine Kinases

Identifiers

PMID22348248
PMCPMC3595018
OpenAlexW2123034574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.