ArticlePLoS neglected tropical diseases2012
Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.
Article in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 55 citations in OpenAlex.
- Peptide-Alkoxyamine Drugs: An Innovative Approach to Fight Schistosomiasis: "Digging Their Graves with Their Forks".Pathogens (Basel, Switzerland) · 2024Article
- Hybrid Peptide-Alkoxyamine Drugs: A Strategy for the Development of a New Family of Antiplasmodial Drugs.Molecules (Basel, Switzerland) · 2024Article
- Article
- Synergistic effect of combination chemotherapy with praziquantel and DW-3-15 for Schistosoma japonicum in vitro and in vivo.Parasites & vectors · 2021Article
- Mitochondria as a Potential Target for the Development of Prophylactic and Therapeutic Drugs against Schistosoma mansoni Infection.Antimicrobial agents and chemotherapy · 2021Article
- Alkoxyamines Designed as Potential Drugs againstMolecules (Basel, Switzerland) · 2020Article
- Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.Journal of medicinal chemistry · 2020Article
- Promethazine exhibits antiparasitic propertiesAntimicrobial agents and chemotherapy · 2019Article
- In vitro and in vivo activities of DW-3-15, a commercial praziquantel derivative, against Schistosoma japonicum.Parasites & vectors · 2019Article
- Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules.Pharmaceuticals (Basel, Switzerland) · 2018Review
- An artemisinin derivative of praziquantel as an orally active antischistosomal agent.PloS one · 2014Article
- Novel therapeutic and prevention approaches for schistosomiasis: review.Journal of advanced research · 2013Review
- Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds.Parasites & vectors · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis is among the most neglected tropical diseases, since its mode of spreading tends to limit the contamination to people who are in contact with contaminated waters in endemic countries. Here we report the in vitro and in vivo anti-schistosomal activities of trioxaquines. These hybrid molecules are highly active on the larval forms of the worms and exhibit different modes of action, not only the alkylation of heme. The synergy observed with praziquantel on infected mice is in favor of the development of these trioxaquines as potential anti-schistosomal agents.
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