ArticlePloS one2012
The transcriptional response of Caenorhabditis elegans to Ivermectin exposure identifies novel genes involved in the response to reduced food intake.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- P-glycoproteins and amphids: a two-stage trajectory of ivermectin resistance in Caenorhabditis elegans.International journal for parasitology. Drugs and drug resistance · 2026Article
- Identification of intestinal mediators ofmBio · 2025Article
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- Use of Viscous medium to study anthelmintic drug action in Caenorhabditis elegans.Scientific reports · 2024Article
- Article
- Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode.PLoS pathogens · 2022Article
- Comparative analysis on transcriptomics of ivermectin resistant and susceptible strains of Haemonchus contortus.Parasites & vectors · 2022Article
- Ivermectin-induced gene expression changes in adult Parascaris univalens and Caenorhabditis elegans: a comparative approach to study anthelminthic metabolism and resistance in vitro.Parasites & vectors · 2022Article
- Cytochromes P450 ofBiomolecules · 2022Review
- Natural variation in Caenorhabditis elegans responses to the anthelmintic emodepside.International journal for parasitology. Drugs and drug resistance · 2021Article
- Phenolic Compounds Reduce the Fat Content inPharmaceuticals (Basel, Switzerland) · 2020Article
- Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour.Parasites & vectors · 2019Article
- Effects of diethylcarbamazine and ivermectin treatment onParasitology open · 2019Article
- Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans.BMC biology · 2018Article
- Transcriptome and Resistance-Related Genes Analysis ofFrontiers in microbiology · 2018Article
- Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.PLoS neglected tropical diseases · 2017Article
- Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.PLoS genetics · 2017Article
- The Effect of Macrocyclic Lactones-Ivermectin Exposure on Egg Hatching and Larval Development ofTropical life sciences research · 2016Article
- The Effects of Ivermectin on Brugia malayi Females In Vitro: A Transcriptomic Approach.PLoS neglected tropical diseases · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
We have examined the transcriptional response of Caenorhabditis elegans following exposure to the anthelmintic drug ivermectin (IVM) using whole genome microarrays and real-time QPCR. Our original aim was to identify candidate molecules involved in IVM metabolism and/or excretion. For this reason the IVM tolerant strain, DA1316, was used to minimise transcriptomic changes related to the phenotype of drug exposure. However, unlike equivalent work with benzimidazole drugs, very few of the induced genes were members of xenobiotic metabolising enzyme families. Instead, the transcriptional response was dominated by genes associated with fat mobilization and fatty acid metabolism including catalase, esterase, and fatty acid CoA synthetase genes. This is consistent with the reduction in pharyngeal pumping, and consequential reduction in food intake, upon exposure of DA1316 worms to IVM. Genes with the highest fold change in response to IVM exposure, cyp-37B1, mtl-1 and scl-2, were comparably up-regulated in response to short-term food withdrawal (4 hr) independent of IVM exposure, and GFP reporter constructs confirm their expression in tissues associated with fat storage (intestine and hypodermis). These experiments have serendipitously identified novel genes involved in an early response of C. elegans to reduced food intake and may provide insight into similar processes in higher organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.