ArticlePloS one2012
High diversity of Cryptosporidium subgenotypes identified in Malaysian HIV/AIDS individuals targeting gp60 gene.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis.Parasite (Paris, France) · 2020Pooled it
- Anthroponotic transmission of Cryptosporidium parvum predominates in countries with poorer sanitation: a systematic review and meta-analysis.Parasites & vectors · 2019Pooled it
- Cryptosporidium parvum: an emerging occupational zoonosis in Finland.Acta veterinaria Scandinavica · 2023Article
- Cross-Border Investigations on the Prevalence and Transmission Dynamics ofMicroorganisms · 2021Article
- Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries.Clinical microbiology reviews · 2021Review
- First Molecular Characterization ofPathogens (Basel, Switzerland) · 2021Article
- Article
- Dairy Calves in Uruguay Are Reservoirs of Zoonotic Subtypes ofFrontiers in veterinary science · 2020Article
- Cryptosporidium spp.: Human incidence, molecular characterization and associated exposures in Québec, Canada (2016-2017).PloS one · 2020Article
- Asymptomatic Cryptosporidium infections in ewes and lambs are a source of environmental contamination with zoonotic genotypes of Cryptosporidium parvum.Parasite (Paris, France) · 2020Article
- Cryptosporidium infection in rural Gambian children: Epidemiology and risk factors.PLoS neglected tropical diseases · 2019Article
- Prevalence and genotypic identification of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in pre-weaned dairy calves in Guangdong, China.Parasites & vectors · 2019Article
- Prevalence of cryptosporidiosis and hygiene practices among HIV/AIDS patients in southwest Uganda.HIV/AIDS (Auckland, N.Z.) · 2019Article
- Zoonotic Cryptosporidium species and subtypes in lambs and goat kids in Algeria.Parasites & vectors · 2018Article
- First detection of Cryptosporidium DNA in blood and cerebrospinal fluid of HIV-infected patients.Parasitology research · 2018Article
- Detection ofBioMed research international · 2017Article
- First molecular investigation of Cryptosporidium spp. in young calves in Algeria.Parasite (Paris, France) · 2017Article
- Natural History of Cryptosporidiosis in a Longitudinal Study of Slum-Dwelling Bangladeshi Children: Association with Severe Malnutrition.PLoS neglected tropical diseases · 2016Article
- Cryptosporidium hominis Is a Newly Recognized Pathogen in the Arctic Region of Nunavik, Canada: Molecular Characterization of an Outbreak.PLoS neglected tropical diseases · 2016Article
- Genetic characterization ofGastroenterology and hepatology from bed to bench · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, there is a lack of vital information in the genetic makeup of Cryptosporidium especially in developing countries. The present study aimed at determining the genotypes and subgenotypes of Cryptosporidium in hospitalized Malaysian human immunodeficiency virus (HIV) positive patients. METHODOLOGY/PRINCIPAL
findingsIn this study, 346 faecal samples collected from Malaysian HIV positive patients were genetically analysed via PCR targeting the 60 kDa glycoprotein (gp60) gene. Eighteen (5.2% of 346) isolates were determined as Cryptosporidium positive with 72.2% (of 18) identified as Cryptosporidium parvum whilst 27.7% as Cryptosporidium hominis. Further gp60 analysis revealed C. parvum belonging to subgenotypes IIaA13G1R1 (2 isolates), IIaA13G2R1 (2 isolates), IIaA14G2R1 (3 isolates), IIaA15G2R1 (5 isolates) and IIdA15G1R1 (1 isolate). C. hominis was represented by subgenotypes IaA14R1 (2 isolates), IaA18R1 (1 isolate) and IbA10G2R2 (2 isolates). CONCLUSIONS/SIGNIFICANCE: These findings highlighted the presence of high diversity of Cryptosporidium subgenotypes among Malaysian HIV infected individuals. The predominance of the C. parvum subgenotypes signified the possibility of zoonotic as well as anthroponotic transmissions of cryptosporidiosis in HIV infected individuals.
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