ArticlePloS one2012
A genome-wide collection of Mos1 transposon insertion mutants for the C. elegans research community.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Modular safe-harbor transgene insertion for targeted single-copy and extrachromosomal array integration in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
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- An efficient negative selection marker formicroPublication biology · 2022Article
- Targeted and Random Transposon-Assisted Single-Copy Transgene Insertion in C. elegans.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The Caenorhabditis elegans CUB-like-domain containing protein RBT-1 functions as a receptor for Bacillus thuringiensis Cry6Aa toxin.PLoS pathogens · 2020Article
- Crossover Position Drives Chromosome Remodeling for Accurate Meiotic Chromosome Segregation.Current biology : CB · 2020Article
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- Functionally non-redundant paralogs spe-47 and spe-50 encode FB-MO associated proteins and interact with him-8.PloS one · 2020Article
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- TheGenetics · 2019Review
- Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans.Virulence · 2018Article
- An Efficient Genome Editing Strategy To Generate Putative Null Mutants inG3 (Bethesda, Md.) · 2018Article
- Evolutionary plasticity in the innate immune function of Akirin.PLoS genetics · 2018Article
- Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.Nature reviews. Genetics · 2017Review
- Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing.G3 (Bethesda, Md.) · 2016Article
- Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.PLoS genetics · 2016Article
- The application of the comet assay to assess the genotoxicity of environmental pollutants in the nematode Caenorhabditis elegans.Environmental toxicology and pharmacology · 2016Article
- MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.PLoS biology · 2016Article
- Targeted genome engineering inCell & bioscience · 2016Review
- Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans.Current biology : CB · 2015Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methods that use homologous recombination to engineer the genome of C. elegans commonly use strains carrying specific insertions of the heterologous transposon Mos1. A large collection of known Mos1 insertion alleles would therefore be of general interest to the C. elegans research community. We describe here the optimization of a semi-automated methodology for the construction of a substantial collection of Mos1 insertion mutant strains. At peak production, more than 5,000 strains were generated per month. These strains were then subject to molecular analysis, and more than 13,300 Mos1 insertions characterized. In addition to targeting directly more than 4,700 genes, these alleles represent the potential starting point for the engineered deletion of essentially all C. elegans genes and the modification of more than 40% of them. This collection of mutants, generated under the auspices of the European NEMAGENETAG consortium, is publicly available and represents an important research resource.
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