ArticleFrontiers in pharmacology2012
Endocannabinoids and the processing of value-related signals.
Article in Frontiers in pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Cannabinoid type-1 receptor signaling in dopaminergic Engrailed-1 expressing neurons modulates motivation and depressive-like behavior.Frontiers in molecular neuroscience · 2024Article
- Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis.International journal of molecular sciences · 2023Article
- Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms.Future pharmacology · 2023Article
- Evidence Lacking for Cannabis Users Slacking: A Longitudinal Analysis of Escalating Cannabis Use and Motivation among Adolescents.Journal of the International Neuropsychological Society : JINS · 2021Article
- Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications.Frontiers in neurology · 2021Review
- Endocannabinoid-Like Lipid Neuromodulators in the Regulation of Dopamine Signaling: Relevance for Drug Addiction.Frontiers in synaptic neuroscience · 2020Review
- The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors.JCI insight · 2019Article
- Acetaldehyde, Motivation and Stress: Behavioral Evidence of an AddictiveFrontiers in behavioral neuroscience · 2017Review
- Salience attribution and its relationship to cannabis-induced psychotic symptoms.Psychological medicine · 2016Article
- Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity.European journal of nutrition · 2016Article
- Role of the endogenous cannabinoid system in nicotine addiction: novel insights.Frontiers in psychiatry · 2015Review
- The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study.Psychopharmacology · 2014Article
- Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future.Frontiers in psychiatry · 2014Review
- Acetaldehyde as a drug of abuse: insight into AM281 administration on operant-conflict paradigm in rats.Frontiers in behavioral neuroscience · 2013Article
- Sex-specific tonic 2-arachidonoylglycerol signaling at inhibitory inputs onto dopamine neurons of Lister Hooded rats.Frontiers in integrative neuroscience · 2013Article
- Endocannabinoids in nervous system health and disease: the big picture in a nutshell.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Article
- Hub and switches: endocannabinoid signalling in midbrain dopamine neurons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Braking dopamine systems: a new GABA master structure for mesolimbic and nigrostriatal functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocannabinoids serve as retrograde signaling molecules at many synapses within the CNS, particularly GABAergic and glutamatergic synapses. Synapses onto midbrain dopamine (DA) neurons in the ventral tegmental area (VTA) make no exception to this rule. In fact, the effects of cannabinoids on dopamine transmission as well as DA-related behaviors are generally exerted through the modulation of inhibitory and excitatory afferents impinging onto DA neurons. Endocannabinoids, by regulating different forms of synaptic plasticity in the VTA, provide a critical modulation of the DA neuron output and, ultimately, of the systems driving and regulating motivated behaviors. Because DA cells exhibit diverse states of activity, which crucially depend on their intrinsic properties and afferent drive, the understanding of the role played by endocannabinoids in synaptic modulations is critical for their overall functions. Particularly, endocannabinoids by selectively inhibiting afferent activity may alter the functional states of DA neurons and potentiate the responsiveness of the reward system to phasic DA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.