ArticleFrontiers in molecular neuroscience2012
Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling.
Article in Frontiers in molecular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Glycogen synthase kinase 3 signaling in neural regeneration in vivo.Journal of molecular cell biology · 2024Review
- Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets.Biomedicines · 2022Review
- GSK3 Is a Central Player in Retinal Degenerative Diseases but a Challenging Therapeutic Target.Cells · 2022Review
- Review
- Review
- Exosomal miR-92b-3p Promotes Chemoresistance of Small Cell Lung Cancer Through the PTEN/AKT Pathway.Frontiers in cell and developmental biology · 2021Article
- Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes.Molecular biology of the cell · 2020Article
- Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration.Cell death and differentiation · 2018Article
- Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration.Cell death and differentiation · 2018Article
- Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Article
- Stereotactic injection of shrna GSK-3β-AAV promotes axonal regeneration after spinal cord injury.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- Article
- MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression.Cell death & disease · 2015Article
- HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway.PloS one · 2015Article
- Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.BMC biology · 2014Article
- Glycogen synthase kinase 3 beta (GSK3β) at the tip of neuronal development and regeneration.Molecular neurobiology · 2014Review
- Cell intrinsic control of axon regeneration.EMBO reports · 2014Review
- Signaling pathways that regulate axon regeneration.Neuroscience bulletin · 2013Review
- MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration.Genes & development · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Axon growth requires the coordinated regulation of gene expression in the neuronal soma, local protein translation in the axon, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. Glycogen synthase kinase 3 (GSK3) signaling has recently been shown to play key roles in the regulation of axonal transport and cytoskeletal assembly during axon growth. GSK3 signaling is also known to regulate gene expression via controlling the functions of many transcription factors, suggesting that GSK3 may be an important regulator of gene transcription supporting axon growth. We review signaling pathways that control local axon assembly at the growth cone and gene expression in the soma during developmental or regenerative axon growth and discuss the potential involvement of GSK3 signaling in these processes, with a particular focus on how GSK3 signaling modulates the function of axon growth-associated transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.