ArticlePLoS pathogens2012
Substance P causes seizures in neurocysticercosis.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Adrenergic signaling during parasitic infections.Frontiers in immunology · 2025Review
- Innate Immune Response to Helminth Infections.Advances in experimental medicine and biology · 2025Review
- Article
- Worm in the Eye: A Case Report of Ocular Neurocysticercosis With Adherent Retinal Cyst.Cureus · 2023Article
- How parasitic larvae affect the brain.eLife · 2023Article
- Does Calcified Neurocysticercosis Affect Migraine Characteristics and Treatment Responsiveness? A Case-Control Study.The American journal of tropical medicine and hygiene · 2022Article
- Substance P-Friend or Foe.Journal of clinical medicine · 2022Article
- Substance P modulates BMSCs migration for tissue repair through NK-1R/CXCR4/p-Akt signal activation.Molecular biology reports · 2022Article
- The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation.Biochemical Society transactions · 2022Review
- Immune System Investigation Using Parasitic Helminths.Annual review of immunology · 2021Review
- The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs.PLoS neglected tropical diseases · 2021Article
- Chronic administration of cryptolepine nanoparticle formulation alleviates seizures in a neurocysticercosis model.Current research in pharmacology and drug discovery · 2021Article
- Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling.PLoS neglected tropical diseases · 2020Article
- Granulomas in parasitic diseases: the good and the bad.Parasitology research · 2020Review
- Taenia solium Cysticercosis and Its Impact in Neurological Disease.Clinical microbiology reviews · 2020Review
- Host immune responses during Taenia solium Neurocysticercosis infection and treatment.PLoS neglected tropical diseases · 2020Review
- Controlling the Host Response in Neurocysticercosis.The American journal of tropical medicine and hygiene · 2019Article
- Solitary Brain Mass in a Patient with Seizures: An Unexpected Infectious Etiology.Diseases (Basel, Switzerland) · 2018Article
- Substance P Regulation in Epilepsy.Current neuropharmacology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Neurocysticercosis (NCC), a helminth infection of the brain, is a major cause of seizures. The mediators responsible for seizures in NCC are unknown, and their management remains controversial. Substance P (SP) is a neuropeptide produced by neurons, endothelial cells and immunocytes. The current studies examined the hypothesis that SP mediates seizures in NCC. We demonstrated by immunostaining that 5 of 5 brain biopsies from NCC patients contained substance P (SP)-positive (+) cells adjacent to but not distant from degenerating worms; no SP+ cells were detected in uninfected brains. In a rodent model of NCC, seizures were induced after intrahippocampal injection of SP alone or after injection of extracts of cysticercosis granuloma obtained from infected wild type (WT), but not from infected SP precursor-deficient mice. Seizure activity correlated with SP levels within WT granuloma extracts and was prevented by intrahippocampal pre-injection of SP receptor antagonist. Furthermore, extracts of granulomas from WT mice caused seizures when injected into the hippocampus of WT mice, but not when injected into SP receptor (NK1R) deficient mice. These findings indicate that SP causes seizures in NCC, and, suggests that seizures in NCC in humans may be prevented and/or treated with SP-receptor antagonists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.