Evidence map›Paper›PMID 22346573›Full record

ReviewSensors (Basel, Switzerland)2011

In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals.

Dan M Close, Tingting Xu, Gary S Sayler, Steven Ripp

Abstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Biomedical optics express · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dan M CloseThe Center for Environmental Biotechnology, 676 Dabney Hall, The University of Tennessee, Knoxville, TN 37996, USA. dclose@utk.edu
Tingting Xu
Gary S Sayler
Steven Ripp

Funding

Development of Noninvasive Bioluminescence Imaging for Cancer Diagnosis and TheraR21CA127745 · NCI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI SAYLER, GARY S · 2007 to 2008
$239k
NCI NIH HHS CA127745-01NCI NIH HHS R21 CA127745
6 · The paper itself

Abstract

In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern biological research. This process, which involves the noninvasive interrogation of living animals using light emitted from luciferase-expressing bioreporter cells, has been applied to study a wide range of biomolecular functions such as gene function, drug discovery and development, cellular trafficking, protein-protein interactions, and especially tumorigenesis, cancer treatment, and disease progression. This article will review the various bioreporter/biosensor integrations of BLI and discuss how BLI is being applied towards a new visual understanding of biological processes within the living organism.

Indexed as

Luminescent MeasurementsAnimalsBiosensing TechniquesGenes, ReporterLuciferasesModels, AnimalLuciferasesbacterial luciferasebioluminescent imagingBLIfirefly luciferaseLucLux

Identifiers

PMID22346573
PMCPMC3274065

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.