ArticleThe Canadian journal of infectious diseases = Journal canadien des maladies infectieuses1998
Platelet depletion and severity of streptococcal endocarditis.
Article in The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Development and validation of a nomogram for predicting in-hospital mortality in ICU patients with infective endocarditis.BMC medical informatics and decision making · 2024Article
- The Role of Platelets in Infective Endocarditis.International journal of molecular sciences · 2023Review
- Evaluation of Infective Endocarditis in Children: A 19-Year Retrospective Study in Taiwan.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the importance of thrombocytopenia in streptococcal endocarditis using an animal model.
designA model of human septic endocarditis was established in rats (polyethylene catheters across the aortic valve and administration of Streptococcus sanguis, 5×10(7) colony forming units [cfu] intravenous). Thrombocytopenia at four levels was produced by antiplatelet serum. Secondary methods of producing thrombocytopenia were also evaluated. At sacrifice (96 h after platelet depletion and 72 h after infection), vegetations were removed, weighed, diluted, plated and counted. Potential mechanisms of the dose-response relationship between vegetation density and platelet count were evaluated.
settingControlled research laboratory experiments. POPULATION STUDIED: Animal models of streptococcal endocarditis. MAIN
resultsThe bacterial density of the aortic valve vegetations significantly increased as the platelet count decreased (P=0.0007). In severely thrombocytopenic animals (two-dose antiplatelet serum), data suggest increased vegetation embolism. Platelet depletion, which was minimal with chemical methods, was produced most effectively by antithrombocyte serum. Platelet surfaces in endocarditis were found to express elevated CD62p proteins (72.7% endocarditis, 34.7% control). Platelet protein fractions were evaluated in vitro by both streptocidal (P=0.19) and phagocytosis-stimulating assays. Platelet presence in mature aortic valve vegetations averaged only about 2%.
conclusionsIn platelet depletion experiments using a rat model, a dose-response relationship of peripheral circulating platelet depletion to aortic valve vegetation density was found. The mechanism relating thrombocytopenia to endocarditis severity remains unresolved.
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Registered trials
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