ArticleThe Canadian journal of infectious diseases = Journal canadien des maladies infectieuses1993
Molecular epidemiology of Candida albicans colonization and fungemia in very low birthweight infants.
Article in The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors at 2 institutions in 2 countries.
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Abstract
objectiveThis study investigated the relationship between colonization and fungemia.
designThis was a prospective study involving surveillance cultures of the nares, base of umbilicus, point of entry of umbilical catheter and parenteral fluids. Blood cultures were done when sepsis was suspected. All Candida albicans isolates were typed using restriction enzyme analysis of DNA.
settingPatients were from the neonatal intensive care unit of a tertiary care hospital. POPULATION STUDIED: Twenty-nine very low birthweight infants. MAIN
resultsEleven babies were colonized with C albicans and five of these babies developed fungemia, including five of seven who were colonized at the point of entry of the umbilical catheter. Three different strains of C albicans caused fungemia. In four of the five patients, initial catheter entry site isolates were identical to the subsequent blood isolates. Occasionally, infants were colonized with more than one strain of C albicans.
conclusionsPreceding colonization with C albicans and, in particular, colonization at the site of entry of umbilical vascular catheters are risk factors for subsequent development of C albicans fungemia. Fungemic and colonizing isolates are usually identical to one another by DNA typing.
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