ArticleJournal of neurosciences in rural practice2012
Role of nitrosative and oxidative stress in neuropathy in patients with type 2 diabetes mellitus.
Article in Journal of neurosciences in rural practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- The Neuroprotective Role of Indole-3-Propionic Acid in Migraine Pathophysiology.Medicina (Kaunas, Lithuania) · 2024Article
- Isolation and antioxidant characterization of theaflavin for neuroprotective effect in mice model.Food science & nutrition · 2023Article
- Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1).Frontiers in microbiology · 2022Article
- Article
- Subcellular microRNAs in diabetic cardiomyopathy.Annals of translational medicine · 2020Review
- Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitriteTurkish journal of medical sciences · 2020Article
- Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography.Oxidative medicine and cellular longevity · 2018Article
- Effect of metabolic control on oxidative stress, subclinical atherosclerosis and peripheral artery disease in diabetic patients.Journal of diabetes and metabolic disorders · 2015Article
- Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes.Journal of diabetes research · 2015Article
- Heart failure in the diabetic population - pathophysiology, diagnosis and management.Archives of medical science : AMS · 2014Article
- Advances in the diagnosis and management of diabetic distal symmetric polyneuropathy.Archives of medical science : AMS · 2014Article
- Absence of clinical relationship between oxidized low density lipoproteins and diabetic peripheral neuropathy: a case control study.Lipids in health and disease · 2014Article
- Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats.American journal of physiology. Endocrinology and metabolism · 2013Article
- Association of dietary vitamin C and e intake and antioxidant enzymes in type 2 diabetes mellitus patients.Global journal of health science · 2013Article
- Curcumin attenuates diabetic neuropathic pain by downregulating TNF-α in a rat model.International journal of medical sciences · 2013Article
- Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy.Molecular biology reports · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEvidences of oxidative and/or nitrosative stress in type 2 diabetes mellitus were demonstrated in experimental and human studies. This study is aimed to assess the serum peroxynitrite and oxidized lipoproteins in patients with type 2 diabetes mellitus presented with clinical and laboratory evidences of peripheral neuropathy. MATERIALS AND
methodsEighty four patients with type 2 diabetes mellitus (51 of them had neuropathy) and 31 apparent healthy subjects were studied in the unit of neurophysiology at the University Hospital of Medical College, Al-Nahrin University in Baghdad, Iraq. Neuropathy total symptom score (NTSS), neuropathy impairment score in the lower leg (NIS-LL), and nerve conduction velocity of sensory (ulnar and sural) and motor (ulnar and common peroneal) nerves were used to assess the neuropathy. Fasting venous blood was obtained from each participant for the determination of serum glucose and oxidized lipoproteins.
resultsThe electrophysiology study revealed significant decrease in conduction velocity of ulnar (sensory and motor components), sural, and common peroneal nerves in diabetic neuropathy compared to diabetics without neuropathy and healthy subjects. Significant high level of serum peroxynitrite was found in diabetic patients with or without neuropathy compared with non-diabetics. The changes in serum-oxidized lipoproteins in patients with diabetics with or without neuropathy were non-significantly differed from healthy subjects. Neither nitrosative stress nor oxidative stress indices correlated with the variables that are related to the neuropathy.
conclusionIt concludes that evidence of nitrosative and to less extent the oxidative stress is associated with neuropathy in type 2 diabetes mellitus and their indices not correlated with variables related to neuropathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.