ArticleJournal of cardiovascular disease research2012
Effect of monosodium glutamate on lipid peroxidation and certain antioxidant enzymes in cardiac tissue of alcoholic adult male mice.
Article in Journal of cardiovascular disease research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Ultra-Processed Foods and Cardiometabolic Health: A Review of Current Evidence.Current nutrition reports · 2025Review
- Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects.Frontiers in pharmacology · 2025Review
- In Vivo and In Vitro Studies Assessing the Safety of Monosodium Glutamate.Foods (Basel, Switzerland) · 2024Article
- Associations of minimally processed and ultra-processed food intakes with cardiovascular health in Korean adults: the Korea National Health and Nutrition Examination Survey (KNHANES VI), 2013-2015.Journal of exposure science & environmental epidemiology · 2024Article
- Food contamination and cardiovascular disease: a narrative review.Internal and emergency medicine · 2024Review
- Ultra-processed foods and cardiovascular disease: analysis of three large US prospective cohorts and a systematic review and meta-analysis of prospective cohort studies.Lancet regional health. Americas · 2024Article
- Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease.BMC medicine · 2023Article
- Associations of ultra-processed food consumption with cardiovascular disease and all-cause mortality: UK Biobank.European journal of public health · 2022Observational
- Neuroprotective Effect of Morin Hydrate against Attention-Deficit/Hyperactivity Disorder (ADHD) Induced by MSG and/or Protein Malnutrition in Rat Pups: Effect on Oxidative/Monoamines/Inflammatory Balance and Apoptosis.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Relationship between Ultra-Processed Food Consumption and Risk of Diabetes Mellitus: A Mini-Review.Nutrients · 2022Review
- Higher Ultra-Processed Food Consumption Is Associated with Increased Risk of Incident Coronary Artery Disease in the Atherosclerosis Risk in Communities Study.The Journal of nutrition · 2021Article
- Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review.Nutrients · 2021Review
- Processed Foods - Getting Back to The Basics.Current gastroenterology reports · 2021Review
- Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats.Scientific reports · 2021Article
- Association between ultraprocessed food intake and cardiovascular health in US adults: a cross-sectional analysis of the NHANES 2011-2016.The American journal of clinical nutrition · 2021Article
- Ultra-Processed Foods and Excess Heart Age Among U.S. Adults.American journal of preventive medicine · 2020Article
- Ameliorative Effect of Graviola (Animals : an open access journal from MDPI · 2020Article
- Article
- Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis.Scientific reports · 2020Article
- High consumption of ultra-processed food may double the risk of subclinical coronary atherosclerosis: the Aragon Workers' Health Study (AWHS).BMC medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMonosodium glutamate (MSG), a sodium salt of glutamic acid is commonly used as flavor enhancer in Chinese, Japanese and ready to serve foods all over the World, is the inducer of oxidative stress. In the present era, MSG and alcohol is becoming a part of daily food. Concomitantly, there is a tremendous increase in the incidences of cardiovascular diseases. So, the present study was designed to elucidate the effect of MSG by evaluating the changes in oxidative stress markers in cardiac tissue of normal and alcoholic adult male mice. MATERIALS AND
methodsAnimals were divided into six groups of six mice each and MSG at dose levels of 0, 4, and 8 mg/g body weight was given orally for seven consecutive days (that is from 31st day to 37(th) day of alcohol ingestion) to chronic alcoholic (30% ethanol/100 g body weight) adult male mice. After the dose period (38(th) day), animals were fasted overnight, sacrificed by decapitation and hearts were removed for the estimation of lipid peroxidation (LPO), xanthine oxidase (XOD), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) and its metabolizing enzymes like glutathione peroxidase (GPx) and glutathione reductase (GR).
resultsA significant (P < 0.001) increase was observed in LPO and XOD levels while a significant decrease (P < 0.001) in the levels of SOD, CAT, GSH, GPx and GR was found in cardiac tissue of normal and alcoholic animals.
conclusionThese observations suggested that oral ingestion of MSG at dose levels of 4 mg/g body weight and above with and without alcohol increased the oxidative stress and thereby, could act as an additional factor for the initiation of atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.