ArticleAnnals of Indian Academy of Neurology2011
Mortality in mechanically ventilated patients of Guillain Barré Syndrome.
Article in Annals of Indian Academy of Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Mechanical ventilation, hospitalization time, deaths and disability according to the variants of Guillain-Barré syndrome: systematic review and meta-analysis.Revista peruana de medicina experimental y salud publica · 2024Pooled it
- Patients' experiences and perceptions of Guillain-Barré syndrome: A systematic review and meta-synthesis of qualitative research.PloS one · 2021Pooled it
- Guillain-Barré syndrome in Colombia: where do we stand now?Immunologic research · 2017Pooled it
- Evolving understanding of Guillain-Barré syndrome pathophysiology and the central role of the classical complement pathway in axonal injury.Frontiers in neurology · 2025Article
- A retrospective analysis of the clinical profile and factors associated with mortality and poor hospital outcomes in adult Guillain-Barre syndrome patients.Scientific reports · 2024Article
- Guillain-barré syndrome (GBS) with antecedent chikungunya infection: a case report and literature review.Neurological research and practice · 2024Review
- Clinical predictors for mechanical ventilation assistance in Guillain-Barré syndrome.Frontiers in neurology · 2024Article
- Immune-Mediated Neuropathies: Pathophysiology and Management.International journal of molecular sciences · 2023Review
- Predicting Mechanical Ventilation Using the EGRIS in Guillain-Barré Syndrome in a Latin American Country.Neurocritical care · 2021Article
- Guillain-Barré syndrome in low-income and middle-income countries: challenges and prospects.Nature reviews. Neurology · 2021Review
- Prolonged Ventilatory Support for Patients Recovering From Guillain-Barré Syndrome.Neurology. Clinical practice · 2021Article
- Inclusion of Mechanical Ventilation in Severity Staging of Tuberculous Meningitis Improves Outcome Prediction.The American journal of tropical medicine and hygiene · 2020Article
- Influenza Vaccination and Guillain-Barré Syndrome: Reality or Fear.Journal of translational internal medicine · 2019Review
- Heart rate variability and baroreflex sensitivity abnormalities in Guillain-Barré syndrome: a pilot study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Risk factors for respiratory failure in Guillain-Barré syndrome in Bangladesh: a prospective study.Annals of clinical and translational neurology · 2019Article
- Changes in the severity and subtype of Guillain-Barré syndrome admitted to a specialist Neuromedical ICU over a 25 year period.Journal of neurology · 2017Article
- Outcome of Guillain-Barre syndrome patients with respiratory paralysis.QJM : monthly journal of the Association of Physicians · 2016Article
- Outcomes for patients with Guillain-Barré syndrome requiring mechanical ventilation: a literature review.Irish journal of medical science · 2016Review
- Predictors for mechanical ventilation and short-term prognosis in patients with Guillain-Barré syndrome.Critical care (London, England) · 2015Article
- Guillain-Barré Syndrome and Human Immunodeficiency Virus.Turkish journal of anaesthesiology and reanimation · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mortality of patients with Guillain Barré syndrome (GBS) has varied widely with rates between 1-18%. Death results from pneumonia, sepsis, adult respiratory distress syndrome (ARDS) and less frequently due to autonomic dysfunction or pulmonary embolism. There are only few studies which have used a large sample and have in detail analyzed the circumstances relating to death and the prognostic factors for the same in a cohort, including only mechanically ventilated patients.
objectiveThe objective of our study was to analyze the circumstances and factors related to mortality in mechanically ventilated patients of GBS. MATERIALS AND
methodsCase records of patients of GBS, satisfying National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) criteria, and requiring mechanical ventilation from 1984 to 2007, were analyzed.
resultsA total of 273 GBS patients were managed with ventilatory support (190 men and 83 women) during the period. Besides symmetrical paralysis in all patients, bulbar palsy was present in 186 (68.1%), sensory involvement in 88 (32.2%) and symptomatic autonomic dysfunction in 72 (26.4%) patients. The mortality was 12.1%. The factors determining mortality were elderly age group (P=0.03), autonomic dysfunction (P=0.03), pulmonary complications (P=0.001), hypokalemia (P=0.001) and bleeding (P=0.001) from any site. Logistic regression analysis showed the risk of mortality was 4.69 times more when pneumonia was present, 2.44 times more when hypokalemia was present, and 3.14 times more when dysautonomia was present. The odds ratio for age was 0.97 indicating that a higher age was associated with a higher risk of mortality.
conclusionsVentilator associated pulmonary complications, bleeding and hypokalemia especially in elderly patients require optimal surveillance and aggressive therapy at the earliest for reducing the mortality in this group of GBS patients.
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