ArticleIndian journal of human genetics2011
Large-scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,797 individuals.
Article in Indian journal of human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Association study between genetic polymorphisms in MTHFR and stroke susceptibility in Egyptian population: a case-control study.Scientific reports · 2024Article
- Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.Bioscience reports · 2019Article
- Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran.Medicina (Kaunas, Lithuania) · 2019Article
- Morphogenetic Variability and Hypertension in Ischemic Stroke Patients-Preliminary Study.Journal of clinical medicine · 2018Article
- Effects of exercise training on stroke risk factors, homocysteine concentration, and cognitive function according theJournal of exercise rehabilitation · 2018Article
- A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype.Scientific reports · 2017Article
- G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco.Biomedical reports · 2016Article
- Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco.Journal of genetics · 2016Article
- Activated Protein C Resistance Does Not Increase Risk for Recurrent Stroke or Death in Stroke Patients.PloS one · 2016Article
- Association of methylenetetrahydrofolate reductase gene (C677T) with the risk of hypertension in Morocco.BMC research notes · 2015Article
- The role of genetic risk factors in arterial ischemic stroke in pediatric and adult patients: a critical review.Molecular biology reports · 2014Review
- Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population.International journal of molecular sciences · 2014Article
- Large scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,297 individuals.Indian journal of human genetics · 2013Article
- Large scale Meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,297 individuals.Indian journal of human genetics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemic stroke descent has a genetic basis. Stroke represents a complex trait, which is assumed to be polygenic. On this topic, the role of a wide number of candidate genes has been investigated in stroke through association studies. MATERIALS AND
methodsWe performed a literature-based systematic review of genetic association studies in stroke abound several populations. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined for each gene-disease association. Following a review of 300 manuscripts, five candidate gene variants were analyzed among 152,797 individuals (45,433 cases and 107,364 controls).
resultsFor these five candidate genes studied, the prothrombin OR is 1,57 (1,23-2,89), the factor V Leiden OR is 1,43 (0,67-6,24), the mean OR of angiotensin I converting enzyme (ACE) insertion/deletion (I/D) polymorphism is 1,11 (1,02-1,25), the summary OR for the C677T variant of 5,10-methylenetetrahydrofolate reductase (MTHFR) is 1,23 (0,61-1,47) and the pooled OR for the apolipoprotein E (APOE) gene is 0,95 (0,77-1,14) .
conclusionThese data suggest the genetic associations of some genes with ischemic stroke and it is necessary to compete with other genes. Our findings could represent an epidemiological base and a useful tool to address further molecular investigations and to realize more detailed meta-analyses.
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