Evidence map›Paper›PMID 22345912›Full record

ArticleLung India : official organ of Indian Chest Society2012

Health-related quality of life assessment using St. George's respiratory questionnaire in asthmatics on inhaled corticosteroids.

Thomas Sabin, Gurumurthy Parthasarathi, Mahesh A Padukudru

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Article in Lung India : official organ of Indian Chest Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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3 · Its place in the literature

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2 citing papers in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Thomas SabinDepartment of Clinical Pharmacy, JSS College of Pharmacy and JSS Medical College Hospital, JSS University, Mysore, India.
Gurumurthy Parthasarathi
Mahesh A Padukudru

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextChronic diseases like asthma have significant effects on patients' health-related quality of life (HRQoL). HRQoL measures additional indices as compared to objective measurements like spirometry.

aimsTo assess and compare disease-specific quality of life in asthma patients using St. George's Respiratory Questionnaire (SGRQ) receiving fluticasone, beclomethasone, and budesonide (BUD). SETTINGS AND

designA prospective, open label, randomized, parallel group study conducted at a tertiary care teaching hospital in South India. MATERIALS AND

methodsA 6-month follow-up of 277 patients with mild, moderate, and severe persistent asthma was randomized to receive fluticasone propionate (FP), BUD, or beclomethasone dipropionate (BDP) in equipotent doses according to their global initiative on asthma (GINA) severity. STATISTICAL ANALYSIS USED: Data analyzed using SPSS version: 13.0. General linear-repeated measures using the post-hoc bonferroni method assessed significance between treatment groups.

resultsSignificant decrease (P < 0.05) in each SGRQ domains and total scores as well as improvement in FEV(1) (P < 0.05) was observed in all study subjects. A significant early response (P < 0.05) was noted after 15 days treatment in patients receiving FP with respect to SGRQ (activity, impact and total) scores and dyspnea indices, but not FEV(1). This improvement with FP was due to its greater effect in patients with moderate and severe persistent asthma. No difference was noted subsequently in all outcome measures studied until 6 months.

conclusionsThere was evidence for an early QoL improvement to FP as compared to BUD or BDP in moderate and severe persistent asthma. Subsequently, the three ICS showed similar improvements in lung functions and dyspnea indices throughout the study.

Indexed as

Asthmahealth-related quality of lifeinhaled corticosteroids

Identifiers

PMID22345912
PMCPMC3276031

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