ArticleIndian journal of dermatology2011
The possible role of trauma in skin tags through the release of mast cell mediators.
Article in Indian journal of dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Penile acrochordon: An unusual site of presentation and the role of the androgen receptors.Urology case reports · 2026Article
- Article
- Novel Treatment for a Giant Acrochordon Using Pachaieruvai, a Traditional Siddha Medicine: A Case Report.Cureus · 2025Article
- A Clinico-Morphological Study of Acrochordons and the Association With Diabetes Mellitus.Cureus · 2025Article
- Article
- Article
- Amelanotic acrochordon.BMJ case reports · 2024Article
- Congenital giant fibroepithelial polyp of the scrotum in an infant: the first case report from China.Frontiers in pediatrics · 2023Article
- Mycosis Fungoides Exhibits the Features of Skin Tags: A Case Report.Clinical, cosmetic and investigational dermatology · 2023Article
- Skin tags: a link between lesional mast cell count/tryptase expression and obesity and dyslipidemia.Indian journal of dermatology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkin tags (ST) are common benign tumors of the skin but their etiopathogenesis is not well understood. STs arise in sites subjected to trauma. It was proved that mast cells are recruited to sites of skin trauma and increase their tumor necrosis factor-α (TNF-α) content.
aimSTs are linked to obesity and frictional sites, but this has not been studied at the molecular level. We hypothesized that mast cells, TNF-α and its family member, TNF-related apoptosis-inducing ligand (TRAIL) might play a role in the pathogenesis of STs as a response to trauma. MATERIALS AND
methodsA study was done on 15 patients with STs. Two STs and a snip of normal skin were obtained in each subject. We counted the mast cells after Toluidine blue staining. Enzyme-linked immunosorbant assay was used to measure TNF-α level while reverse transcriptase polymerase chain reaction was used to evaluate the level of TRAIL mRNA expression.
resultsMast cell count in all STs was significantly higher than that in control (P=0.0355). There was a highly significant increase in the level of TNF-α in all STs as compared to its level in controls (P<0.0001). Expression of TRAIL mRNA was significantly higher in STs as compared to its expression in controls (P<0.0001).
conclusionOur study suggests that mast cells, TNF-α and TRAIL may play a role in the pathogenesis of STs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.