Evidence map›Paper›PMID 22345659›Full record

ArticleGut2013

The Oslo definitions for coeliac disease and related terms.

Jonas F Ludvigsson, Daniel A Leffler, Julio C Bai, Federico Biagi, Alessio Fasano, Peter H R Green, Marios Hadjivassiliou, Katri Kaukinen, Ciaran P Kelly, Jonathan N Leonard and 6 more

4 registry-linked trialsOpen access · bronzeAbstract readConsensus Statement
In one paragraph

Article in Gut, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 652 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
652citing papers in PubMed, 10 pooled it
81.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02823522 completednot on this mapstarted 2016, after this paper: background citation

Non-Celiac Wheat Sensitivity: Permanent or Transient Condition? A Follow-up Study

TypeobservationalSponsorUniversity of PalermoRan2016 to 2025Enrolled280ConditionsNon-Celiac Wheat SensitivityArmsPatients recruitment
NCT03866538 phase4terminatednot on this mapstarted 2019, after this paper: background citation

Open-label Withdrawal Trial of Budesonide in Patients With Immune Mediated Enteropathies

TypeinterventionalSponsorMayo ClinicRan2019 to 2021Enrolled1ConditionsEnteropathy, Celiac Disease, CVID Enteropathy, Collagenous SprueArmsWithdrawal of Oral Budesonide
NCT04351828 completednot on this mapstarted 2018, after this paper: background citation

The Investigation of Nutritional Status, Intestinal Permeability and Quality of Life in People With Celiac Disease

TypeobservationalSponsorMarmara UniversityRan2018 to 2019Enrolled44ConditionsCeliac Disease, Nutritional Deficiency, Quality of LifeArmsBlood draw once a time
NCT07563582 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Oral Sucrosomial Iron Supplementation in Children With Celiac Disease and Iron Deficiency or Anemia: a Double-blind, Randomized, Placebo-controlled Trial

TypeinterventionalSponsorIstituto Giannina GasliniRan2025 to 2027Enrolled60ConditionsCeliac Disease in Children, Anemia, Iron DeficienciesArmsSideral forte® VERUM drops, Sideral forte® matching PLACEBO drops
3 · Its place in the literature

Who cites it

652 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,666 citations in OpenAlex.

  1. Guideline
  2. Prevalence of Celiac Disease in Patients With Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Pooled it
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  4. A Meta-Synthesis Exploring Daily Experiences of Adults With Coeliac Disease in Adhering to a Gluten-Free Diet.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Pooled it
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  11. Trial
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  14. Article
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592 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 15 institutions in 7 countries.

Jonas F LudvigssonDivision of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.
Daniel A Leffler
Julio C Bai
Federico Biagi
Alessio Fasano
Peter H R Green
Marios Hadjivassiliou
Katri Kaukinen
Ciaran P Kelly
Jonathan N Leonard
Knut Erik Aslaksen Lundin
Joseph A Murray
David S Sanders
Marjorie M Walker
Fabiana Zingone
Carolina Ciacci
Royal Hallamshire Hospital · GBBeth Israel Deaconess Medical Center · USColumbia University · USHarvard University · USMayo Clinic · USÖrebro University Hospital · SEOslo University Hospital · NOSt Mary's Hospital · GBSt Mary's Hospital · GBTampere University · FIUniversidad del Salvador · ARUniversity of Maryland, Baltimore · USUniversity of Naples Federico II · ITUniversity of Pavia · ITUniversity of Salerno · IT

Funding

Non-invasive markers of celiac disease activity during gluten challengeK23DK082619 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LEFFLER, DANIEL ALEXANDER · 2009 to 2013
$887k
Validation of Peripheral Microparticles as Novel Biomarkers of Celiac Disease ActR03DK095937 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LEFFLER, DANIEL ALEXANDER · 2013 to 2014
$174k
NIDDK NIH HHS DK1042103881NIDDK NIH HHS K23 DK082619NIDDK NIH HHS R03 DK095937
6 · The paper itself

Abstract

objectiveThe literature suggests a lack of consensus on the use of terms related to coeliac disease (CD) and gluten.

designA multidisciplinary task force of 16 physicians from seven countries used the electronic database PubMed to review the literature for CD-related terms up to January 2011. Teams of physicians then suggested a definition for each term, followed by feedback of these definitions through a web survey on definitions, discussions during a meeting in Oslo and phone conferences. In addition to 'CD', the following descriptors of CD were evaluated (in alphabetical order): asymptomatic, atypical, classical, latent, non-classical, overt, paediatric classical, potential, refractory, silent, subclinical, symptomatic, typical, CD serology, CD autoimmunity, genetically at risk of CD, dermatitis herpetiformis, gluten, gluten ataxia, gluten intolerance, gluten sensitivity and gliadin-specific antibodies.

resultsCD was defined as 'a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals'. Classical CD was defined as 'CD presenting with signs and symptoms of malabsorption. Diarrhoea, steatorrhoea, weight loss or growth failure is required.' 'Gluten-related disorders' is the suggested umbrella term for all diseases triggered by gluten and the term gluten intolerance should not to be used. Other definitions are presented in the paper.

conclusionThis paper presents the Oslo definitions for CD-related terms.

Indexed as

Celiac DiseaseTerminology as TopicAsymptomatic DiseasesDermatitis HerpetiformisDiet, Gluten-FreeGenetic MarkersGlutensHumansPhenotypeRecurrenceGenetic MarkersGlutens

Identifiers

PMID22345659
PMCPMC3440559
OpenAlexW2116287226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.