Evidence map›Paper›PMID 22345594›Full record

ReviewArteriosclerosis, thrombosis, and vascular biology2012

Mechanistic view of risk factors for venous thromboembolism.

Pieter H Reitsma, Henri H Versteeg, Saskia Middeldorp

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Arteriosclerosis, thrombosis, and vascular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07287007 (Evaluating the Hemodynamic Performance of the VenAir Sequential Compression System), which is not on this map. Cited by 79 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 4 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07287007 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating the Hemodynamic Performance of the VenAir Sequential Compression System

TypeinterventionalSponsorWellell Inc. TaiwanRan2025 to 2026Enrolled105ConditionsNo Condition, Healthy Individuals, No Conditions, Aged 20-64ArmsVenAir, SCD700
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 207 citations in OpenAlex.

  1. Pooled it
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  9. Heparin: Over 100 Years of Anticoagulation.Handbook of experimental pharmacology · 2026
    Review
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  20. Double bad luck: pulmonary embolism and vaginal bleeding - a case report.International journal of emergency medicine · 2024
    Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pieter H ReitsmaDepartment of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. p.h.reitsma@lumc.nl
Henri H Versteeg
Saskia Middeldorp
Academic Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venous thromboembolism is an episodic disease with an annual incidence of 2 to 3/1000 per year that is associated with a high morbidity and mortality. Risk factors for venous thromboembolism come in many guises. They fit into an extended version of Virchow's triad and they tilt the hemostatic balance toward clot formation. This can be achieved by decreasing blood flow and lowering oxygen tension, by activating the endothelium, by activating innate or acquired immune responses, by activating blood platelets, or by increasing the number of platelets and red blood cells or modifying the concentrations of pro- and anticoagulant proteins in the blood. In this narrative review we will discuss the known common risk factors within this pathophysiological framework.

Indexed as

Blood CoagulationAdaptive ImmunityAnimalsBlood PlateletsCell-Derived MicroparticlesEndothelial CellsErythrocytesHumansImmunity, InnateInflammation MediatorsOxygenRegional Blood FlowRisk AssessmentRisk FactorsVenous ThromboembolismInflammation MediatorsOxygen

Identifiers

PMID22345594
OpenAlexW1966613914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.