ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction.Molecular metabolism · 2023Article
- Cell Signaling Pathways in Mammary Carcinoma Induced in Rats with Low versus High Inherent Aerobic Capacity.International journal of molecular sciences · 2019Article
- Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain.Brain and behavior · 2017Article
- Inherent aerobic capacity-dependent differences in breast carcinogenesis.Carcinogenesis · 2017Article
- Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes.Cardiovascular diabetology · 2017Article
- Association of physical performance and biochemical profile of mice with intrinsic endurance swimming.International journal of medical sciences · 2016Article
- Elevated Myocardial Oxygen Consumption During Cutaneous Cold Stress in Young Adult Overweight and Obese Africans.Journal of public health in Africa · 2015Article
- Label-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity.Proteomics · 2015Article
- Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity.Acta physiologica (Oxford, England) · 2014Article
- Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance.Dose-response : a publication of International Hormesis Society · 2014Article
- Association between prehypertension, metabolic and inflammatory markers, decreased adiponectin and enhanced insulinemia in obese subjects.Nutrition & metabolism · 2014Article
- Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance.Metabolism: clinical and experimental · 2013Review
- Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a Western diet.Endocrinology · 2013Article
- Rats selectively bred for differences in aerobic capacity have similar hypertensive responses to chronic intermittent hypoxia.American journal of physiology. Heart and circulatory physiology · 2013Article
- Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male Zucker obese rats.Endocrinology · 2013Article
- Diabetes mellitus and vascular disease.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.Life sciences · 2013Review
- Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function.American journal of physiology. Heart and circulatory physiology · 2013Article
- Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity.Physiological genomics · 2013Article
- Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice.Endocrinology · 2013Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The statistical association between endurance exercise capacity and cardiovascular disease suggests that impaired aerobic metabolism underlies the cardiovascular disease risk in men and women. To explore this connection, we applied divergent artificial selection in rats to develop low-capacity runner (LCR) and high-capacity runner (HCR) rats and found that disease risks segregated strongly with low running capacity. Here, we tested if inborn low aerobic capacity promotes differential sex-related cardiovascular effects. Compared with HCR males (HCR-M), LCR males (LCR-M) were overweight by 34% and had heavier retroperitoneal, epididymal, and omental fat pads; LCR females (LCR-F) were 20% heavier than HCR females (HCR-F), and their retroperitoneal, but not perireproductive or omental, fat pads were heavier as well. Unlike HCR-M, blood pressure was elevated in LCR-M, and this was accompanied by left ventricular (LV) hypertrophy. Like HCR-F, LCR-F exhibited normal blood pressure and LV weight as well as increased spontaneous cage activity compared with males. Despite normal blood pressures, LCR-F exhibited increased myocardial interstitial fibrosis and diastolic dysfunction, as indicated by increased LV stiffness, a decrease in the initial filling rate, and an increase in diastolic relaxation time. Although females exhibited increased arterial stiffness, ejection fraction was normal. Increased interstitial fibrosis and diastolic dysfunction in LCR-F was accompanied by the lowest protein levels of phosphorylated AMP-actived protein kinase [phospho-AMPK (Thr(172))] and silent information regulator 1. Thus, the combination of risk factors, including female sex, intrinsic low aerobic capacity, and overweightness, promote myocardial stiffness/fibrosis sufficient to induce diastolic dysfunction in the absence of hypertension and LV hypertrophy.
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Registered trials
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