ArticleAJNR. American journal of neuroradiology2012
Carotid atherosclerotic plaque progression and change in plaque composition over time: a 5-year follow-up study using serial CT angiography.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.AJNR. American journal of neuroradiology · 2018Guideline
- Glycemic Index Versus Wheat Fiber on Arterial Wall Damage in Diabetes: A Randomized Controlled Trial.Diabetes care · 2022Trial
- Carotid CTA at the Lowest Tube Voltage (70 kV) in Comparison with Automated Tube Voltage Adaption.AJNR. American journal of neuroradiology · 2019Trial
- Carotid Plaque Lipid Content and Fibrous Cap Status Predict Systemic CV Outcomes: The MRI Substudy in AIM-HIGH.JACC. Cardiovascular imaging · 2017 · on this mapTrial
- Correlation between fissured fibrous cap and contrast enhancement: preliminary results with the use of CTA and histologic validation.AJNR. American journal of neuroradiology · 2014Trial
- Local and systemic factors associated with quantitative stiffness of carotid plaque.Acta neurochirurgica · 2024Article
- Human Plaque Myofibroblasts to Study Mechanisms of Atherosclerosis.Journal of the American Heart Association · 2023Article
- Imaging Approaches to the Diagnosis of Vascular Diseases.Current atherosclerosis reports · 2022Review
- Dynamic Changes of Carotid Atherosclerosis and Their Relation with Stroke Recurrence in Patients with Stroke or Transient Ischemic Attack.Current neurovascular research · 2022Article
- Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability.Therapeutics and clinical risk management · 2021Article
- Ultrasound methods of imaging atherosclerotic plaque in carotid arteries: examinations using contrast agents.Journal of ultrasonography · 2020Article
- Plaque imaging volume analysis: technique and application.Cardiovascular diagnosis and therapy · 2020Review
- Carotid artery plaque characterization with a wide-detector computed tomography using a dedicated post-processing 3D analysis: comparison with histology.La Radiologia medica · 2019Article
- Carotid calcifications in panoramic radiographs are associated with future stroke or ischemic heart diseases: a long-term follow-up study.Clinical oral investigations · 2019Article
- Isolation, culturing and gene expression profiling of inner mass cells from stable and vulnerable carotid atherosclerotic plaques.PloS one · 2019Article
- New developments in clinical ischemic stroke prevention and treatment and their imaging implications.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Comparison of CT and CMR for detection and quantification of carotid artery calcification: the Rotterdam Study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Article
- A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics.Gene regulation and systems biology · 2017Article
- Longitudinal assessment of carotid atherosclerosis after Radiation Therapy using Computed Tomography: A case control Study.European radiology · 2016Observational
- MR imaging-detected carotid plaque hemorrhage is stable for 2 years and a marker for stenosis progression.AJNR. American journal of neuroradiology · 2015Article
Corrections and comments
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSerial in vivo imaging of atherosclerosis is important for understanding plaque progression and is potentially useful in predicting cardiovascular events and monitoring treatment efficacy. This prospective study aims to quantify temporal changes in carotid atherosclerotic plaque volume and plaque composition using MDCTA. MATERIALS AND
methodsIn 109 patients with TIA or ischemic stroke, serial MDCTA of the carotid arteries was performed after 5.3 ± 0.7 years. The carotid bifurcation was semiautomatically registered for paired baseline follow-up datasets. Outer vessel wall and lumen boundaries were defined using semiautomated segmentation tools. Plaque component volumes were measured using HU thresholds. Annual changes in plaque volume and plaque component proportions were calculated.
resultsOne-hundred-ninety-three carotid arteries were analyzed. Plaque volume decreased in 31% and increased in 69% of vessels (range -5.6-10.1%/year). Overall, plaque volume increased 1.2% per year (95% CI, 0.8-1.6, P ≤ .001). Plaque composition changed significantly from BL (fibrous 66.4%, lipid 28.8%, calcifications 4.8%): fibrous tissue decreased by 1.5%, lipid decreased by 1.8%, and calcification increased by 3.3% (P < .001). Intraobserver reproducibility of all volume and proportion measurements was good (ICC 0.78-1.00) and interobserver reproducibility was moderate (ICC 0.76-0.99).
conclusionsChanges in carotid plaque burden and plaque composition can be quantified by using serial MDCTA. Plaque burden development is a heterogeneous and slow process.
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