ArticleSocial cognitive and affective neuroscience2013
Serotonin transporter genotype modulates cognitive reappraisal of negative emotions: a functional magnetic resonance imaging study.
Article in Social cognitive and affective neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Associations between genetic risk, functional brain network organization and neuroticism.Brain imaging and behavior · 2017Article
- Emotion regulation deficits in regular marijuana users.Human brain mapping · 2017Article
- Neural and Genetic Correlates of the Social Sharing of Happiness.Frontiers in neuroscience · 2017Article
- Genetic and neural correlates of romantic relationship satisfaction.Social cognitive and affective neuroscience · 2016Article
- 5-HTTLPR differentially predicts brain network responses to emotional faces.Human brain mapping · 2015Article
- Recent advances in the genetics of emotion regulation: a review.Current opinion in psychology · 2015Article
- Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study.PloS one · 2015Article
- Connectivity underlying emotion conflict regulation in older adults with 5-HTTLPR short allele: a preliminary investigation.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- General and specific effects of early-life psychosocial adversities on adolescent grey matter volume.NeuroImage. Clinical · 2014Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A functional polymorphism within the serotonin transporter gene (5-HTTLPR) has been reported to modulate emotionality and risk for affective disorders. The short (S) allele has less functional efficacy than the long (L) allele and has been associated with enhanced emotional reactivity. One possible contributing factor to the high emotionality in S carriers may be inefficient use of cognitive strategies such as reappraisal to regulate emotional responses. The aim of the present study was to test whether the 5-HTTLPR genotype modulates the neural correlates of emotion regulation. To determine neural differences between S and L allele carriers during reappraisal of negative emotions, 15 homozygous S (S'/S') and 15 homozygous L (L'/L') carriers underwent functional magnetic resonance imaging (fMRI), while performing an instructed emotion regulation task including downregulation, upregulation and passive viewing of negative emotional pictures. Compared to L'/L' allele carriers, subjects who carry the S'/S' allele responded with lower posterior insula and prefrontal brain activation during passive perception of negative emotional information but showed greater prefrontal activation and anterior insula activation during down- and upregulation of negative emotional responses. The current results support and extend previous findings of enhanced emotionality in S carriers by providing additional evidence of 5-HTTLPR modulation of volitional emotion regulation.
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