ArticleHuman brain mapping2013
Ventral striatal prediction error signaling is associated with dopamine synthesis capacity and fluid intelligence.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Brain network dysfunctions in addiction: a meta-analysis of resting-state functional connectivity.Translational psychiatry · 2022Pooled it
- The IMAGEN study: a decade of imaging genetics in adolescents.Molecular psychiatry · 2020Pooled it
- Separate neural representations of prediction error valence and surprise: Evidence from an fMRI meta-analysis.Human brain mapping · 2018Pooled it
- Reinforcement learning models and their neural correlates: An activation likelihood estimation meta-analysis.Cognitive, affective & behavioral neuroscience · 2015Pooled it
- Pharmacological Enhancement of Dopamine Neurotransmission Does Not Affect Illusory Pattern Perception.eNeuro · 2024Trial
- Dose-dependent effects of estrogen on prediction error related neural activity in the nucleus accumbens of healthy young women.Psychopharmacology · 2020Trial
- Learning Mechanisms in Alcohol Use Disorders.Addiction biology · 2026Review
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- Effects of Adult Age and Functioning of the Locus Coeruleus Norepinephrinergic System on Reward-Based Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The relationship between resting-state amplitude fluctuations and memory-related deactivations of the default mode network in young and older adults.Human brain mapping · 2023Article
- Insular and Striatal Correlates of Uncertain Risky Reward Pursuit in Schizophrenia.Schizophrenia bulletin · 2023Article
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- Children's Greenness Exposure and IQ-Associated DNA Methylation: A Prospective Cohort Study.International journal of environmental research and public health · 2021Article
- Personalized Estimates of Brain Structural Variability in Individuals With Early Psychosis.Schizophrenia bulletin · 2021Article
- Neural correlates of RDoC-specific cognitive processes in a high-functional autistic patient: a statistically validated case report.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- [The IMAGEN cohort: perspectives and problems of longitudinal research].Der Nervenarzt · 2021Review
- Rational inattention and tonic dopamine.PLoS computational biology · 2021Article
- Is There a Correlation Between the Number of Brain Cells and IQ?Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Striatal Dopamine and Reward Prediction Error Signaling in Unmedicated Schizophrenia Patients.Schizophrenia bulletin · 2020Article
- Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.Schizophrenia research · 2019Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 4 countries.
Funding
Abstract
Fluid intelligence represents the capacity for flexible problem solving and rapid behavioral adaptation. Rewards drive flexible behavioral adaptation, in part via a teaching signal expressed as reward prediction errors in the ventral striatum, which has been associated with phasic dopamine release in animal studies. We examined a sample of 28 healthy male adults using multimodal imaging and biological parametric mapping with (1) functional magnetic resonance imaging during a reversal learning task and (2) in a subsample of 17 subjects also with positron emission tomography using 6-[(18) F]fluoro-L-DOPA to assess dopamine synthesis capacity. Fluid intelligence was measured using a battery of nine standard neuropsychological tests. Ventral striatal BOLD correlates of reward prediction errors were positively correlated with fluid intelligence and, in the right ventral striatum, also inversely correlated with dopamine synthesis capacity (FDOPA K inapp). When exploring aspects of fluid intelligence, we observed that prediction error signaling correlates with complex attention and reasoning. These findings indicate that individual differences in the capacity for flexible problem solving relate to ventral striatal activation during reward-related learning, which in turn proved to be inversely associated with ventral striatal dopamine synthesis capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.