ArticleApplied and environmental microbiology2012
Identification of Avian pathogenic Escherichia coli genes that are induced in vivo during infection in chickens.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Avian pathogenicVeterinary world · 2024Review
- Avian PathogenicPathogens (Basel, Switzerland) · 2021Review
- Genome evolution and the emergence of pathogenicity in avian Escherichia coli.Nature communications · 2021Article
- Function and Regulation of the Pyruvate Transporter CstA inInternational journal of molecular sciences · 2020Article
- Validation of Predicted Virulence Factors inToxins · 2019Article
- Redox, amino acid, and fatty acid metabolism intersect with bacterial virulence in the gut.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Disinfection by hydrogen peroxide nebulization increases susceptibility to avian pathogenic Escherichia coli.BMC research notes · 2015Article
- Human and avian extraintestinal pathogenic Escherichia coli: infections, zoonotic risks, and antibiotic resistance trends.Foodborne pathogens and disease · 2013Review
- Sequencing and functional annotation of avian pathogenic Escherichia coli serogroup O78 strains reveal the evolution of E. coli lineages pathogenic for poultry via distinct mechanisms.Infection and immunity · 2013Article
- Structure of Escherichia coli RutC, a member of the YjgF family and putative aminoacrylate peracid reductase of the rut operon.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Avian pathogenic Escherichia coli (APEC) is associated with extraintestinal infections in poultry causing a variety of diseases collectively known as colibacillosis. The host and bacterial factors influencing and/or responsible for carriage and systemic translocation of APEC inside the host are poorly understood. Identification of such factors could help in the understanding of its pathogenesis and in the subsequent development of control strategies. Recombination-based in vivo expression technology (RIVET) was used to identify APEC genes specifically expressed during infection in chickens. A total of 21 clones with in vivo-induced promoters were isolated from chicken livers and spleens, indicative of systemic infection. DNA sequencing of the cloned fragments revealed that 12 of the genes were conserved E. coli genes (metH, lysA, pntA, purL, serS, ybjE, ycdK [rutC], wcaJ, gspL, sdsR, ylbE, and yjiY), 6 of the genes were phage related/associated, and 3 genes were pathogen specific (tkt1, irp2, and eitD). These genes are involved in various cellular functions, such as metabolism, cell envelope and integrity, transport systems, and virulence. Others were phage related or have yet-unknown functions.
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