ArticleApplied and environmental microbiology2012
Lytic activity of LysH5 endolysin secreted by Lactococcus lactis using the secretion signal sequence of bacteriocin Lcn972.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- The Unique Capability of Endolysin to Tackle Antibiotic Resistance: Cracking the Barrier.Journal of xenobiotics · 2025Review
- Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications.Infectious diseases and therapy · 2025Review
- A comparative guide to expression systems for phage lysin production.Essays in biochemistry · 2024Review
- Review
- Wild-typeFrontiers in microbiology · 2023Article
- Article
- Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety.Microorganisms · 2020Review
- Role of Bacteriophages in the Implementation of a Sustainable Dairy Chain.Frontiers in microbiology · 2019Review
- Downstream Processing ofFrontiers in bioengineering and biotechnology · 2019Article
- Recombinant Endolysins as Potential Therapeutics against Antibiotic-Resistant Staphylococcus aureus: Current Status of Research and Novel Delivery Strategies.Clinical microbiology reviews · 2018Review
- Bacteriophage endolysins and their applications.Science progress · 2016Article
- Bacteriophages as Weapons Against Bacterial Biofilms in the Food Industry.Frontiers in microbiology · 2016Review
- Biocontrol and Rapid Detection of Food-Borne Pathogens Using Bacteriophages and Endolysins.Frontiers in microbiology · 2016Review
- Mitrecin A, an endolysin-like bacteriolytic enzyme from a newly isolated soil streptomycete.Letters in applied microbiology · 2014Article
- Antimicrobial peptides targeting Gram-negative pathogens, produced and delivered by lactic acid bacteria.ACS synthetic biology · 2013Article
- Expression and lytic efficacy assessment of the Staphylococcus aureus phage SA4 lysin gene.Journal of veterinary science · 2013Article
- Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus.Applied microbiology and biotechnology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophage endolysins have an interesting potential as antimicrobials. The endolysin LysH5, encoded by Staphylococcus aureus phage vB_SauS-phi-IPLA88, was expressed and secreted in Lactococcus lactis using the signal peptide of bacteriocin lactococcin 972 and lactococcal constitutive and inducible promoters. Up to 80 U/mg of extracellular active endolysin was detected in culture supernatants, but most of the protein (up to 323 U/mg) remained in the cell extracts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.