Evidence map›Paper›PMID 22344608›Full record

ReviewPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2012

Applications of p-hydroxyphenacyl (pHP) and coumarin-4-ylmethyl photoremovable protecting groups.

Richard S Givens, Marina Rubina, Jakob Wirz

Abstract readReview
In one paragraph

Review in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Heterolysis vs Homolysis andThe Journal of organic chemistry · 2026
    Article
  3. Review
  4. Article
  5. Developing Photoactive Coumarin-CagedMolecules (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Light in a Heartbeat: Bond Scission by a Single Photon above 800 nm.Journal of the American Chemical Society · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Towards Upcycling Biomass-Derived Crosslinked Polymers with Light.Angewandte Chemie (International ed. in English) · 2022
    Article
  13. Light-Sensitive Phenacyl Crosslinked Dextran Hydrogels for Controlled Delivery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  14. Crystal structure of 2-oxo-1,2-di-phenyl-ethyl diiso-propyl-carbamate.Acta crystallographica. Section E, Crystallographic communications · 2021
    Article
  15. Optical control of adenosine APharmacological research · 2021
    Article
  16. Crystal structure of 2-oxo-2-phenyl-ethyl diiso-propyl-carbamate.Acta crystallographica. Section E, Crystallographic communications · 2021
    Article
  17. Article
  18. Dynamic Structural Biology Experiments at XFEL or Synchrotron Sources.Methods in molecular biology (Clifton, N.J.) · 2021
    Review
  19. Article
  20. Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard S GivensDepartment of Chemistry, University of Kansas, Kansas, USA. givensr@ku.edu
Marina Rubina
Jakob Wirz

Funding

Light activated bioactive substrate releaseR01GM072910 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI GIVENS, RICHARD SPENCER · 2005 to 2008
$906k
NIGMS NIH HHS R01 GM072910NIGMS NIH HHS R01GM72910
6 · The paper itself

Abstract

Most applications of photoremovable protecting groups have used o-nitrobenzyl compounds and their (often commercially available) derivatives that, however, have several disadvantages. The focus of this review is on applications of the more recently developed title compounds, which are especially well suited for time-resolved biochemical and physiological investigations, because they release the caged substrates in high yield within a few nanoseconds or less. Together, these two chromophores cover the action spectrum for photorelease from >700 nm to 250 nm.

Indexed as

CoumarinsMolecular StructurePhenylacetatesPhotolysisTime Factors4-hydroxyphenylacetic acidCoumarinsPhenylacetates

Identifiers

PMID22344608
PMCPMC3422890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.