Evidence map›Paper›PMID 22344196›Full record

ArticleThe Journal of clinical endocrinology and metabolism2012

Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging.

Siobán D Harlow, Margery Gass, Janet E Hall, Roger Lobo, Pauline Maki, Robert W Rebar, Sherry Sherman, Patrick M Sluss, Tobie J de Villiers, STRAW + 10 Collaborative Group

3 registry-linked trialsAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 572 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
572citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05961371 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Strength Training for Osteoporosis Prevention During Early Menopause

TypeinterventionalSponsorUniversity of CalgaryRan2023 to 2025Enrolled40ConditionsBone Loss, Bone Loss, Age-related, Osteoporosis, Musculoskeletal DiseasesArmsResistance Training
NCT07021664 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Santé, Imagerie et Cognition à Travers la Transition ménopausique

TypeobservationalSponsorUniversité de SherbrookeRan2025 to 2026Enrolled45ConditionsMenopause
NCT07615777 narecruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot Study Investigating the Effects of a Nutritional Supplement on Physiological and Metabolic Markers in 38-55-year-old Females

TypeinterventionalSponsorUniversity of SouthamptonRan2026 to 2026Enrolled80ConditionsPerimenopausal Women, Body Composition ChangesArmsNutritional Supplement, Placebo
3 · Its place in the literature

Who cites it

572 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  14. Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024
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512 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siobán D HarlowDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor MI 48109, USA. harlow@umich.edu
Margery Gass
Janet E Hall
Roger Lobo
Pauline Maki
Robert W Rebar
Sherry Sherman
Patrick M Sluss
Tobie J de Villiers
STRAW + 10 Collaborative Group

Funding

STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBMR13AG039961 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 2011 to 2011
$54k
NIA NIH HHS R13 AG039961
6 · The paper itself

Abstract

objectiveThe aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period.

methodsScientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimüllerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus.

resultsSTRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage -1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics.

conclusionsSTRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified.

Indexed as

AgingReproductionWomen's HealthAgedAged, 80 and overBiomedical ResearchEndocrine System DiseasesFemaleHumansHypothalamo-Hypophyseal SystemMenopauseMiddle AgedOvaryPostmenopause

Identifiers

PMID22344196
PMCPMC3319184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.