ArticleCirculation2012
Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-up Study.
Article in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 9 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
160 citing papers in PubMed, 9 syntheses or guidelines pooled it, 296 citations in OpenAlex.
- Maternal Overnutrition in Pregnancy Predicts Greater Body Mass Index Gains in Offspring by Early Midlife: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Body mass index in parents and their adult offspring: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024Pooled it
- Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis.Paediatric and perinatal epidemiology · 2022Pooled it
- The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review.Frontiers in endocrinology · 2022Pooled it
- Maternal nutrition and its intergenerational links to non-communicable disease metabolic risk factors: a systematic review and narrative synthesis.Journal of health, population, and nutrition · 2021Pooled it
- Maternal overnutrition impairs offspring's insulin sensitivity: A systematic review and meta-analysis.Maternal & child nutrition · 2020Pooled it
- Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE-Moms Prospective Meta-Analysis.Obesity (Silver Spring, Md.) · 2018Pooled it
- Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review.Maternal & child nutrition · 2018Pooled it
- Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017Pooled it
- Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial.Frontiers in endocrinology · 2023Trial
- Trial
- Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Trial
- Supporting healthful lifestyles during pregnancy: a health coach intervention pilot study.BMC pregnancy and childbirth · 2018Trial
- A randomised controlled demonstration trial of multifaceted nutritional intervention and or probiotics: the healthy mums and babies (HUMBA) trial.BMC pregnancy and childbirth · 2016Trial
- Low-protein formula slows weight gain in infants of overweight mothers.Journal of pediatric gastroenterology and nutrition · 2014Trial
- Representativeness of participants in a lifestyle intervention study in obese pregnant women - the difference between study participants and non-participants.Obesity facts · 2014Trial
- Sex-dependent epigenomic and transcriptomic reprogramming links maternal obesity to cardiac remodeling in adult offspring.American journal of physiology. Heart and circulatory physiology · 2026Article
- Maternal obesity programs offspring metabolic dysfunction via small extracellular vesicle-mediated epigenetic remodeling.Nature communications · 2026Article
- Optimizing the Postpartum Period to Support Lifelong Health for Women with Obesity.Current obesity reports · 2026Review
- Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring.Experimental physiology · 2026Review
100 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAccumulating evidence demonstrates that both maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) are associated with adult offspring adiposity. However, whether these maternal attributes are related to other cardiometabolic risk factors in adulthood has not been comprehensively studied. METHODS AND
resultsWe used a birth cohort of 1400 young adults born in Jerusalem who had extensive archival data and clinical information at 32 years of age to prospectively examine the associations of mppBMI and GWG with adiposity and related cardiometabolic outcomes. Greater mppBMI, independently of GWG and confounders, was significantly associated with higher offspring BMI, waist circumference, systolic and diastolic blood pressures, insulin, and triglycerides and with lower high-density lipoprotein cholesterol. For example, the effect sizes were translated to nearly 5 kg/m(2) higher mean BMI, 8.4 cm higher waist circumference, 0.13 mmol/L (11.4 mg/dL) higher triglycerides, and 0.10 mmol/L (3.8 mg/dL) lower high-density lipoprotein cholesterol among offspring of mothers within the upper mppBMI quartile (mppBMI >26.4 kg/m(2)) compared with the lower quartile (mppBMI <21.0 kg/m(2)). GWG, independently of mppBMI, was positively associated with offspring adiposity; differences of 1.6 kg/m(2) in BMI and 2.4 cm in waist were observed when offspring of mothers in the upper (GWG >14 kg) and lower (GWG <9 kg) quartiles of GWG were compared. Further adjustment for offspring adiposity attenuated the observed associations to the null.
conclusionsMaternal size both before and during pregnancy is associated with cardiometabolic risk factors in young adult offspring. The associations appear to be driven mainly by offspring adiposity. Future studies that explore mechanisms underlying the intergenerational cycle of obesity are warranted to identify potentially novel targets for cardiometabolic risk-reduction interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.