ArticleObesity (Silver Spring, Md.)2012
Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging.
Article in Obesity (Silver Spring, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 85 citations in OpenAlex.
- Evaluation of high-fat diet-induced metabolic impairments in iBAT lipid metabolism usingMagma (New York, N.Y.) · 2026Article
- Optimizing CT-Based Models for Predicting Whole-Body Fat in Rabbits.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- Automatic segmentation of the interscapular brown adipose tissue in rats based on deep learning using the dynamic magnetic resonance fat fraction images.Magma (New York, N.Y.) · 2024Article
- Article
- Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Quantification of brown adipose tissueQuantitative imaging in medicine and surgery · 2022Article
- Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021Review
- Sex-dependent effects of forced exercise in the body composition of adolescent rats.Scientific reports · 2021Article
- Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [Molecular imaging and biology · 2020Article
- Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (BRIGHT Study).Physiological research · 2020Article
- Characterization of brown adipose tissue (BAT) in polycystic ovary syndrome (PCOS) patients by Z-Spectral Imaging (ZSI).European journal of radiology · 2020Article
- Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.Frontiers in endocrinology · 2020Review
- Morphology of the Vasculature and Blood Supply of the Brown Adipose Tissue Examined in an Animal Model by Micro-CT.BioMed research international · 2020Article
- 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.Nature metabolism · 2019Article
- Effects of exercise on brown and beige adipocytes.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- Evaluation of Active Brown Adipose Tissue by the Use of Hyperpolarized [1-International journal of molecular sciences · 2018Article
- PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [Molecular imaging and biology · 2018Article
- Non-invasive methods for the assessment of brown adipose tissue in humans.The Journal of physiology · 2018Review
- Non-invasive Imaging Methods for Brown Adipose Tissue Detection and Function Evaluation.Internal medicine: open access · 2018Article
- Spectral Unmixing Imaging for Differentiating Brown Adipose Tissue Mass and Its Activation.Contrast media & molecular imaging · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Brown adipose tissue (BAT) is the primary tissue responsible for nonshivering thermogenesis in mammals. The amount of BAT and its level of activation help regulate the utilization of excessive calories for thermogenesis as opposed to storage in white adipose tissue (WAT) which would lead to weight gain. Over the past several years, BAT activity in vivo has been primarily assessed by positron emission tomography-computed tomography (PET-CT) scan using 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) to measure glucose utilization associated with BAT mitochondrial respiration. In this study, we demonstrate the feasibility of mapping and estimating BAT volume and metabolic function in vivo in rats at a 9.4T magnetic resonance imaging (MRI) scanner using sequences available from clinical MR scanners. Based on the morphological characteristics of BAT, we measured the volume distribution of BAT with MRI sequences that have strong fat-water contrast. We also investigated BAT volume by utilizing spin-echo MRI sequences. The in vivo MRI-estimated BAT volumes were correlated with direct measurement of BAT mass from dissected samples. Using MRI, we also were able to map hemodynamic responses to changes in BAT metabolism induced pharmacologically by β3-adrenergic receptor agonist, CL-316,243 and compare this to BAT activity in response to CL-316,243 assessed by PET 18F-FDG. In conclusion, we demonstrate the feasibility of measuring BAT volume and function in vivo using routine MRI sequences. The MRI measurement of BAT volume is consistent with quantitative measurement of the tissue ex vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.