ArticleNature nanotechnology2012
Engineering controllable bidirectional molecular motors based on myosin.
Article in Nature nanotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Power Strokes in Molecular Motors: Predictive, Irrelevant, or Somewhere in Between?Journal of the American Chemical Society · 2025Article
- Exploitation of Engineered Light-Switchable Myosin XI for Nanotechnological Applications.ACS nano · 2023Article
- The Antiparallel Coiled-Coil Domain Allows Multiple Forward Step Sizes of Myosin X.The journal of physical chemistry letters · 2023Article
- An unexpected non-conjugated AIEgen with a discrete dimer for pure intermolecular through-space charge transfer emission.Chemical science · 2021Article
- Optical control of fast and processive engineered myosins in vitro and in living cells.Nature chemical biology · 2021Article
- Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains.Nature communications · 2020Article
- Positional Isomers of a Non-Nucleoside Substrate Differentially Affect Myosin Function.Biophysical journal · 2020Article
- Synthetic biology approaches to dissecting linear motor protein function: towards the design and synthesis of artificial autonomous protein walkers.Biophysical reviews · 2020Review
- Molecular dynamics simulation of the nanosecond pulsed electric field effect on kinesin nanomotor.Scientific reports · 2019Article
- Structure and dynamics of rotary VCellular and molecular life sciences : CMLS · 2018Review
- Controllable molecular motors engineered from myosin and RNA.Nature nanotechnology · 2018Article
- Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Ensemble velocity of non-processive molecular motors with multiple chemical states.Interface focus · 2014Article
- Molecular motors: Shifting gears with light.Nature nanotechnology · 2014Article
- Remote control of myosin and kinesin motors using light-activated gearshifting.Nature nanotechnology · 2014Article
- Molecular motors: DNA takes control.Nature nanotechnology · 2014Article
- Engineering myosins for long-range transport on actin filaments.Nature nanotechnology · 2014Article
- Controlled clockwise and anticlockwise rotational switching of a molecular motor.Nature nanotechnology · 2013Article
- Engineered, harnessed, and hijacked: synthetic uses for cytoskeletal systems.Trends in cell biology · 2012Review
- Kinetic properties and small-molecule inhibition of human myosin-6.FEBS letters · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cytoskeletal motors drive the transport of organelles and molecular cargoes within cells and have potential applications in molecular detection and diagnostic devices. Engineering molecular motors with controllable properties will allow selective perturbation of mechanical processes in living cells and provide optimized device components for tasks such as molecular sorting and directed assembly. Biological motors have previously been modified by introducing activation/deactivation switches that respond to metal ions and other signals. Here, we show that myosin motors can be engineered to reversibly change their direction of motion in response to a calcium signal. Building on previous protein engineering studies and guided by a structural model for the redirected power stroke of myosin VI, we have constructed bidirectional myosins through the rigid recombination of structural modules. The performance of the motors was confirmed using gliding filament assays and single fluorophore tracking. Our strategy, in which external signals trigger changes in the geometry and mechanics of myosin lever arms, should make it possible to achieve spatiotemporal control over a range of motor properties including processivity, stride size and branchpoint turning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.