ArticleJournal of bacteriology2012
Transcriptional organization and physiological contributions of the relQ operon of Streptococcus mutans.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Pyruvate metabolism is involved in adaptability and cariogenicity ofJournal of oral microbiology · 2026Review
- Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci.Journal of bacteriology · 2023Article
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- The Pta-AckA Pathway Regulates LrgAB-Mediated Pyruvate Uptake inMicroorganisms · 2020Article
- Peptides encoded in theMicrobiology (Reading, England) · 2020Article
- Manganese Depletion Leads to Multisystem Changes in the Transcriptome of the Opportunistic PathogenFrontiers in microbiology · 2020Article
- Pleiotropic Effects of Bacterial Small Alarmone Synthetases: Underscoring the Dual-Domain Small Alarmone Synthetases inFrontiers in microbiology · 2020Review
- Regulation of (p)ppGpp and Its Homologs on Environmental Adaptation, Survival, and Pathogenicity of Streptococci.Frontiers in microbiology · 2020Review
- Effects of Arginine on Streptococcus mutans Growth, Virulence Gene Expression, and Stress Tolerance.Applied and environmental microbiology · 2017Article
- CcpA and CodY Coordinate Acetate Metabolism in Streptococcus mutans.Applied and environmental microbiology · 2017Article
- An Essential Role for (p)ppGpp in the Integration of Stress Tolerance, Peptide Signaling, and Competence Development in Streptococcus mutans.Frontiers in microbiology · 2016Article
- From (p)ppGpp to (pp)pGpp: Characterization of Regulatory Effects of pGpp Synthesized by the Small Alarmone Synthetase of Enterococcus faecalis.Journal of bacteriology · 2015Article
- Genetics and Physiology of Acetate Metabolism by the Pta-Ack Pathway of Streptococcus mutans.Applied and environmental microbiology · 2015Article
- Manganese uptake and streptococcal virulence.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2015Review
- Evolutionary and population genomics of the cavity causing bacteria Streptococcus mutans.Molecular biology and evolution · 2013Article
- Identification of the Streptococcus mutans LytST two-component regulon reveals its contribution to oxidative stress tolerance.BMC microbiology · 2012Article
- MS_RHII-RSD, a dual-function RNase HII-(p)ppGpp synthetase from Mycobacterium smegmatis.Journal of bacteriology · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The molecular alarmone (p)ppGpp functions as a global regulator of gene expression in bacteria. In Streptococcus mutans, (p)ppGpp synthesis is catalyzed by three gene products: RelA, RelP, and RelQ. RelA is responsible for (p)ppGpp production during a stringent response, and RelP is the primary source of (p)ppGpp during exponential growth, but the role of RelQ has not been thoroughly investigated. In this study, we analyzed the four-gene relQ operon to establish how these gene products may affect homeostasis and stress tolerance in the dental caries pathogen S. mutans. Northern blotting and reverse transcriptase PCR demonstrated that relQ is cotranscribed with the downstream genes ppnK (NAD kinase), rluE (pseudouridine synthase), and pta (phosphotransacetylase). In addition, a promoter located within the rluE gene was shown to drive transcription of pta. Inactivation of relQ, ppnK, or rluE did not significantly affect growth of or stress tolerance by S. mutans, whereas strains lacking pta were more sensitive to acid and oxidative stresses. Interestingly, introduction of an rluE deletion into the pta mutant reversed the deleterious effects of the pta mutation on growth and stress tolerance. Accumulation of (p)ppGpp was also decreased in a pta mutant strain, whereas inactivation of relQ caused enhanced (p)ppGpp synthesis in exponential-phase cells. The results reveal an important role for the relQ operon in the expression of traits that are essential for persistence and pathogenesis by S. mutans and provide evidence for a molecular connection of acetate and (p)ppGpp metabolism with tolerance of acid and oxidative stresses.
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