Evidence map›Paper›PMID 22343226›Full record

ReviewClinical obstetrics and gynecology2012

The oviduct and ovarian cancer: causality, clinical implications, and "targeted prevention".

Christopher P Crum, Frank D McKeon, Wa Xian

Open access · greenAbstract readReview
In one paragraph

Review in Clinical obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Systematic review and meta-analysis on the impact of the levonorgestrel-releasing intrauterine system in reducing risk of ovarian cancer.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022
    Pooled it
  2. Pathologic findings at risk-reducing salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG-0199.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014
    Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. A bespoke target selection tool to guide biomarker discovery in tubo-ovarian cancer.Computational and structural biotechnology journal · 2022
    Article
  9. Article
  10. Methylomic Landscapes of Ovarian Cancer Precursor Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. A Resident's Perspective of Ovarian Cancer.Diagnostics (Basel, Switzerland) · 2017
    Article
  19. Ovarian Cancer Incidence Corrected for Oophorectomy.Diagnostics (Basel, Switzerland) · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Christopher P CrumDepartment of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ccrum@partners.org
Frank D McKeon
Wa Xian
Agency for Science, Technology and Research · SGBrigham and Women's Hospital · USHarvard University Press · US

Funding

MURINE P73 IN TUMORIGENESISR01CA075340 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MCKEON, FRANK D. · 1998 to 2007
$2.8M
P63 IN EPITHELIAL CELL PROLIFERATION AND DIFFERENTIATIONR01CA083944 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MCKEON, FRANK D. · 2000 to 2004
$2.2M
p53 signatures and pelvic serous carcinomaR21CA124688 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CRUM, CHRISTOPHER PAUL · 2007 to 2009
$420k
NCI NIH HHS R01 CA075340NCI NIH HHS R01 CA083944NCI NIH HHS R21 CA124688
6 · The paper itself

Abstract

A novel origin for pelvic serous cancer (ovarian cancer) has been proposed in the distal oviduct. This has important implications, including both early detection in high-risk women and wisdom of relying on serological tests to detect a disease that begins so close to the peritoneal surfaces. With the recent discovery of premalignant disturbances in gene function in the tubal mucosa, the concept of targeted prevention is emerging whereby the interruption of a portion of the carcinogenic pathway will prevent cancer. This alternative to detect early malignancy is a new paradigm in the quest to prevent this deadly disease.

Indexed as

BRCA1 ProteinBRCA2 ProteinCarcinoma in SituCell Transformation, NeoplasticCystadenocarcinoma, SerousEarly DiagnosisFallopian Tube NeoplasmsFallopian TubesFemaleGenes, BRCA1Genes, BRCA2Genetic Predisposition to DiseaseHumansMutationOvarian NeoplasmsOvariectomyBRCA1 ProteinBRCA2 ProteinTumor Suppressor Protein p53

Identifiers

PMID22343226
PMCPMC3319355
OpenAlexW2001111275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.