Evidence map›Paper›PMID 22343182›Full record

ReviewMolecular and biochemical parasitology2012

Monoaminergic signaling as a target for anthelmintic drug discovery: receptor conservation among the free-living and parasitic nematodes.

Richard Komuniecki, Wen Jing Law, Aaron Jex, Peter Geldhof, John Gray, Bruce Bamber, Robin B Gasser

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular and biochemical parasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. A New Antagonist ofFrontiers in neuroscience · 2020
    Article
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  6. Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Richard KomunieckiDepartment of Biological Sciences, The University of Toledo, Toledo, OH 43606, United States. rkomuni@uoft02.utoledo.edu
Wen Jing Law
Aaron Jex
Peter Geldhof
John Gray
Bruce Bamber
Robin B Gasser
University of Toledo · USUniversity of Melbourne · AUGhent University · BE

Funding

Locomotion in Parasitic NematodesR01AI072644 · NIAID · UNIVERSITY OF TOLEDO · PI KOMUNIECKI, RICHARD WALTER · 2008 to 2012
$1.6M
NIAID NIH HHS R01 AI072644
6 · The paper itself

Abstract

This review is designed to summarize the information on monoamine-dependent paralysis as a target for anthelmintic development, examine the conservation of monoamine receptors in the genomes of both free-living and parasitic nematodes, and highlight the utility of the Caenorhabditis elegans model system for dissecting the monoaminergic modulation of locomotory decision-making.

Indexed as

Drug DiscoveryAminesAnimalsAntinematodal AgentsHelminth ProteinsHumansNematodaNematode InfectionsPhylogeographyReceptors, Cell SurfaceSignal TransductionAminesAntinematodal AgentsHelminth ProteinsReceptors, Cell Surface

Identifiers

PMID22343182
PMCPMC3403675
OpenAlexW2034716196

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.