Trial reportJournal of acquired immune deficiency syndromes (1999)2012
Altered vaginal microbiota are associated with perinatal mother-to-child transmission of HIV in African women from Burkina Faso.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The vaginal microbiota: what have we learned after a decade of molecular characterization?PloS one · 2014Pooled it
- Lactic acid produced by optimal vaginal Lactobacillus spp. potently and specifically inactivates HIV-1 in vitro by targeting the viral RNA genome and reverse transcriptase.PLoS pathogens · 2025Article
- Article
- Composition of the vaginal microbiota during pregnancy in women living in sub-Saharan Africa: a PRISMA-compliant review.BMC pregnancy and childbirth · 2021Review
- Recent Advances and New Challenges in Cisgender Women's Gynecologic and Obstetric Health in the Context of HIV.Clinical obstetrics and gynecology · 2021Review
- A New Look at the GenusMicroorganisms · 2021Article
- tidyMicro: a pipeline for microbiome data analysis and visualization using the tidyverse in R.BMC bioinformatics · 2021Article
- Group B Streptococcus and the vaginal microbiome among pregnant women: a systematic review.PeerJ · 2021Article
- Review
- Article
- Protocol for a Longitudinal Analysis of the Vaginal Microbiome from a Pregnant Cohort of African Women in Nigeria.International journal of MCH and AIDS · 2020Article
- Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and prevention.American journal of obstetrics and gynecology · 2019Review
- Highly diverse anaerobe-predominant vaginal microbiota among HIV-infected pregnant women in Zambia.PloS one · 2019Article
- Article
- Oral microbiota in youth with perinatally acquired HIV infection.Microbiome · 2018Article
- A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa.Scientific reports · 2017Article
- Immune development in HIV-exposed uninfected children born to HIV-infected women.Revista do Instituto de Medicina Tropical de Sao Paulo · 2017Article
- Association of high-risk sexual behaviour with diversity of the vaginal microbiota and abundance of Lactobacillus.PloS one · 2017Article
- HIV-induced immunosuppression is associated with colonization of the proximal gut by environmental bacteria.AIDS (London, England) · 2016Article
- Prevalent high-risk HPV infection and vaginal microbiota in Nigerian women.Epidemiology and infection · 2016Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundMother-to-child transmission (MTCT) of HIV remains a significant problem in resource-limited settings, despite the advent of antiretroviral therapies. Because perturbations in vaginal microbial communities are associated with sexual transmission of HIV, we determined whether perinatal MTCT is associated with the vaginal microbiotas of HIV-infected mothers.
methodsWe conducted a retrospective analysis of cervicovaginal microbiotas by pyrosequencing of bacterial 16S rRNA genes (median 350 sequences per sample) from 10 transmitters and 54 nontransmitters during a perinatal MTCT prevention clinical trial of azidothymidine and the microbicide benzalkonium chloride. Logistic regression was performed adjusting for multiple covariates, including CD4(+) T-cell numbers and treatment group, to correlate abundances of microbial taxa with perinatal MTCT.
resultsThe vaginal microbiotas of these subjects were dominated by several lactobacilli species, although a subset of subjects was colonized by diverse anaerobic species. MTCT of HIV was associated with significantly greater relative abundances of several groups of microorganisms. Most notably, among the abundant bacterial species, Gardnerella vaginalis was significantly enriched in cases of antepartum transmission, compared with nontransmission (odds ratio 1.7; P = 0.004). Neither azidothymidine nor benzalkonium chloride treatment was associated with shifts in microbial distributions compared with the placebo control group.
conclusionsThese data suggest that alterations in vaginal microbial communities are associated with an increased risk for perinatal MTCT, consistent with results with horizontal transmission of HIV. Therefore, determining the mucosal features associated with alterations in vaginal microbial communities may guide efforts to modulate the risk for HIV MTCT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.