ReviewMolecular and cellular endocrinology2012
Structure, function and regulation of gonadotropin receptors - a perspective.
Review in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 119 citations in OpenAlex.
- Dose-dependent stimulation of human follicular steroidogenesis by a novel rhCG during ovarian stimulation with fixed rFSH dosing.Frontiers in endocrinology · 2022Trial
- Genetic variants (LhcgrBiology of sex differences · 2025Article
- Unraveling the Clinical FSH Conundrum: Insights From the Small Ovarian Reserve Heifer Model.Molecular reproduction and development · 2025Review
- Cell non-autonomous signaling through the conserved C. elegans glycoprotein hormone receptor FSHR-1 regulates cholinergic neurotransmission.PLoS genetics · 2024Article
- Prenatal DEHP exposure induces lifelong testicular toxicity by continuously interfering with steroidogenic gene expression.Translational andrology and urology · 2024Article
- Allosteric Regulation of G-Protein-Coupled Receptors: From Diversity of Molecular Mechanisms to Multiple Allosteric Sites and Their Ligands.International journal of molecular sciences · 2023Review
- Luteinizing hormone receptor promotes angiogenesis in ovarian endothelial cells of Macaca fascicularis and Homo sapiens†.Biology of reproduction · 2023Article
- A Narrative Review Discussing the Efficiency of Personalized Dosing Algorithm of Follitropin Delta for Ovarian Stimulation and the Reproductive and Clinical Outcomes.Diagnostics (Basel, Switzerland) · 2023Review
- Pre-puberty cannabichromene exposure modulates reproductive function via alteration of spermatogenesis, steroidogenesis, and eNOS pathway metabolites.Toxicology reports · 2023Article
- cAMP-Dependent Signaling and Ovarian Cancer.Cells · 2022Review
- High-Altitude Stress Orchestrates mRNA Expression and Alternative Splicing of Ovarian Follicle Development Genes in Tibetan Sheep.Animals : an open access journal from MDPI · 2022Article
- Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-FunctionJournal of the Endocrine Society · 2022Article
- Gut Steroids and Microbiota: Effect of Gonadectomy and Sex.Biomolecules · 2022Article
- A randomized, controlled, first-in-patient trial of choriogonadotropin beta added to follitropin delta in women undergoing ovarian stimulation in a long GnRH agonist protocol.Human reproduction (Oxford, England) · 2022Article
- Metabolite Comparison between Serum and Follicular Fluid of Dairy Cows with Inactive Ovaries Postpartum.Animals : an open access journal from MDPI · 2022Article
- Estrogenic Modulation of Retinal Sensitivity in Reproductive Female Túngara Frogs.Integrative and comparative biology · 2021Article
- A Prepubertal Mice Model to Study the Growth Pattern of Early Ovarian Follicles.International journal of molecular sciences · 2021Article
- Luteinizing hormone and the aging brain.Vitamins and hormones · 2021Review
- Regulation of Female Folliculogenesis by Tsp1a in Nile Tilapia (International journal of molecular sciences · 2020Article
- CNS luteinizing hormone receptor activation rescues ovariectomy-related loss of spatial memory and neuronal plasticity.Neurobiology of aging · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Luteinizing hormone receptor and follicle stimulating hormone receptor play a crucial role in female and male reproduction. Significant new information has emerged about the structure, mechanism of activation, and regulation of expression of these receptors. Here we provide an overview of the current information on those aspects with an in-depth discussion of the recent developments in the post-transcriptional mechanism of LH receptor expression mediated by a specific LH receptor mRNA binding protein, designated as LRBP. LRBP was identified by electrophoretic gel mobility shift assay using cytosolic fractions from ovaries in the down regulated state. LRBP was purified, its binding site on LH receptor mRNA was identified and characterized. During ligand-induced down regulation, LRBP expression is increased through the cAMP/PKA and ERK signaling pathway, is translocated to translating ribosomes, binds LH receptor mRNA and forms an untranslatable ribonucleoprotein complex. This complex is then routed to the mRNA degradation machinery resulting in diminished levels of both LHR mRNA and cell surface expression of LH receptor. The studies leading to these conclusions are presented.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.