ArticleMolecular and cellular endocrinology2012
Weight gain increases human aromatase expression in mammary gland.
Article in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- High-fat diet attenuates estradiol's efficacy on cognitive function and hippocampal synaptic plasticity in middle-aged ovariectomized mice.Physiological reports · 2026Article
- Obesity-Associated Breast Cancer: Analysis of Risk Factors and Current Clinical Evaluation.Advances in experimental medicine and biology · 2024Review
- PCP4/PEP19 upregulates aromatase gene expression via CYP19A1 promoter I.1 in human breast cancer SK-BR-3 cells.Oncotarget · 2018Article
- Aromatase expression and regulation in breast and endometrial cancer.Journal of molecular endocrinology · 2016Review
- Calorie intake, olive oil consumption and mammographic density among Spanish women.International journal of cancer · 2014Article
- Adult weight gain, fat distribution and mammographic density in Spanish pre- and post-menopausal women (DDM-Spain).Breast cancer research and treatment · 2012Article
- The discrepancy of aromatase expression in epicardial adipose tissue between CHD and non-CHD patients.Cardiovascular journal of AfricaArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Adulthood weight gain predicts estrogen receptor-positive breast cancer. Because local estrogen excess in the breast likely contributes to cancer development, and aromatase is the key enzyme in estrogen biosynthesis, we investigated the role of local aromatase expression in weight gain-associated breast cancer risk in a humanized aromatase (Arom(hum)) mouse model containing the coding region and the 5'-regulatory region of the human aromatase gene. Compared with littermates on normal chow, female Arom(hum) mice on a high fat diet gained more weight, and had a larger mammary gland mass with elevated total human aromatase mRNA levels via promoters I.4 and II associated with increased levels of their regulators TNFα and C/EBPβ. There was no difference in total human aromatase mRNA levels in gonadal white adipose tissue. Our data suggest that diet-induced weight gain preferentially stimulates local aromatase expression in the breast, which may lead to local estrogen excess and breast cancer risk.
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Registered trials
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