ArticlePhysiology & behavior2012
Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning.
Article in Physiology & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03766191 (The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children
Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Motivational dysregulation with melanocortin 4 receptor haploinsufficiency.NeuroImmune pharmacology and therapeutics · 2024Article
- α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity.Acta pharmacologica Sinica · 2023Article
- Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation.Physiology & behavior · 2023Article
- Inter-individual variability amplified through breeding reveals control of reward-related action strategies by Melanocortin-4 Receptor in the dorsomedial striatum.Communications biology · 2022Article
- Activation of Basolateral Amygdala to Nucleus Accumbens Projection Neurons Attenuates Chronic Corticosterone-Induced Behavioral Deficits in Male Mice.Frontiers in behavioral neuroscience · 2021Article
- Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between Attention-Deficit/Hyperactivity Disorder and obesity measures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The melanocortin pathway and control of appetite-progress and therapeutic implications.The Journal of endocrinology · 2019Review
- Motivational valence is determined by striatal melanocortin 4 receptors.The Journal of clinical investigation · 2018Article
- DNA methylation in demyelinated multiple sclerosis hippocampus.Scientific reports · 2017Article
- The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances.Neuroendocrinology · 2017Review
- Melanocortin-4 receptor-regulated energy homeostasis.Nature neuroscience · 2016Review
- Genetic Similarities between Compulsive Overeating and Addiction Phenotypes: A Case for "Food Addiction"?Current psychiatry reports · 2015Review
- Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation.Molecular metabolism · 2015Article
- Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus.Diabetes · 2015Article
- Cross interaction of melanocortinergic and dopaminergic systems in neural modulation.International journal of physiology, pathophysiology and pharmacology · 2015Article
- MC4R expression in pedunculopontine nucleus involved in the modulation of midbrain dopamine system.International journal of clinical and experimental pathology · 2015Article
- Association between MC4R rs17782313 polymorphism and overeating behaviors.International journal of obesity (2005) · 2015Article
- Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice.Endocrinology · 2014Article
- Synaptic changes induced by melanocortin signalling.Nature reviews. Neuroscience · 2014Review
- Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum.Frontiers in neuroanatomy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
It is now widely recognized that exposure to palatable foods engages reward circuits that promote over-eating and facilitate the development of obesity. While the melanocortin 4 receptor (MC4R) has previously been shown to regulate food intake and energy expenditure, little is known about its role in food reward. We demonstrate that MC4R is co-expressed with the dopamine 1 receptor (D1R) in the ventral striatum. While MC4R-null mice are hyperphagic and obese, they exhibit impairments in acquisition of operant responding for a high fat reinforcement. Restoration of MC4R signaling in D1R neurons normalizes procedural learning without affecting motivation to obtain high fat diet. MC4R signaling in D1R neurons is also required for learning in a non-food-reinforced version of the cued water maze. Finally, MC4R signaling in neostriatal slices increases phosphorylation of the Thr34 residue of DARPP-32, a protein phosphatase-1 inhibitor that regulates synaptic plasticity. These data identify a novel requirement for MC4R signaling in procedural memory learning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.