ArticlePsychiatry research2012
Cognitive endophenotypes of psychosis within dimension and diagnosis.
Article in Psychiatry research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Childhood Trauma and Neurocognition in Adults With Psychotic Disorders: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2019Pooled it
- Cognitive Dysfunction as a Risk Factor for Psychosis.Current topics in behavioral neurosciences · 2023Article
- Neurocognition and its association with adverse childhood experiences and familial risk of mental illness.Progress in neuro-psychopharmacology & biological psychiatry · 2022Article
- Identification of pleiotropy at the gene level between psychiatric disorders and related traits.Translational psychiatry · 2021Article
- Heterogeneity of Outcomes and Network Connectivity in Early-Stage Psychosis: A Longitudinal Study.Schizophrenia bulletin · 2021Article
- Using Two-Step Cluster Analysis and Latent Class Cluster Analysis to Classify the Cognitive Heterogeneity of Cross-Diagnostic Psychiatric Inpatients.Frontiers in psychology · 2020Article
- Longitudinal trajectory of early functional recovery in patients with first episode psychosis.Schizophrenia research · 2019Article
- A symptom-based continuum of psychosis explains cognitive and real-world functional deficits better than traditional diagnoses.Schizophrenia research · 2019Article
- Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective.Neuropsychology review · 2018Review
- Assessment of Cognition in Schizophrenia Using Trail Making Test: A Meta-Analysis.Psychiatry investigation · 2018Article
- Differentiating between clinical and behavioral phenotypes in first-episode psychosis during maintenance of visuospatial working memory.Schizophrenia research · 2018Article
- Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains.Psychological medicine · 2018Article
- A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Transcriptome Alterations in Prefrontal Pyramidal Cells Distinguish Schizophrenia From Bipolar and Major Depressive Disorders.Biological psychiatry · 2017Article
- Explicit and implicit reinforcement learning across the psychosis spectrum.Journal of abnormal psychology · 2017Article
- Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls.Schizophrenia bulletin · 2017Article
- Transdiagnostic impairment of cognitive control in mental illness.Journal of psychiatric research · 2016Review
- Using human brain imaging studies as a guide toward animal models of schizophrenia.Neuroscience · 2016Review
- Neurobiology of Risk for Bipolar Disorder.Current treatment options in psychiatry · 2016Review
- Alterations in hippocampal connectivity across the psychosis dimension.Psychiatry research · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
This study sought to characterize the psychosis phenotype, contrasting cognitive features within traditional diagnosis and psychosis dimension in a family sample containing both schizophrenia and psychotic bipolar I disorder. Seventy-six probands with psychosis [44 probands with schizophrenia, 32 probands with psychotic bipolar I disorder] and 55 first-degree relatives [30 relatives of schizophrenia probands, 25 relatives of bipolar probands] were recruited. Standardized clinical and neuropsychological measures were administered. No differences in cognitive performance emerged between probands with schizophrenia and probands with psychotic bipolar disorder, or between relatives of probands with schizophrenia and relatives of probands with bipolar disorder in the domains of working and declarative memory, executive function and attention. Relatives overall showed higher cognitive performance compared to probands, as expected. However, when we segmented the probands and relatives along a psychosis dimension, independent of diagnostic groups, results revealed lower cognitive performance in probands compared to relatives without psychosis spectrum disorders, whereas relatives with psychosis spectrum disorders showed an intermediate level of performance across all cognitive domains. In this study, cognitive performance did not distinguish either probands or their first-degree relatives within traditional diagnostic groups (schizophrenia and psychotic bipolar disorder), but distinguished probands and relatives with and without lifetime psychosis manifestations independent of diagnostic categories. These data support the notion that schizophrenia and psychotic bipolar disorder present a clinical continuum with overlapping cognitive features defining the psychosis phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.