ArticleBiomaterials2012
The use of silica coated MnO nanoparticles to control MRI relaxivity in response to specific physiological changes.
Article in Biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- Applications and Biological Activity of Nanoparticles of Manganese and Manganese Oxides in In Vitro and In Vivo Models.Nanomaterials (Basel, Switzerland) · 2021Review
- Article
- Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents.Chemical Society reviews · 2017Review
- Article
- Relaxivity and toxicological properties of manganese oxide nanoparticles for MRI applications.RSC advances · 2016Article
- In vitro cytotoxic evaluation of MgO nanoparticles and their effect on the expression of ROS genes.International journal of molecular sciences · 2015Article
- Tumor-targeted responsive nanoparticle-based systems for magnetic resonance imaging and therapy.Pharmaceutical research · 2014Article
- Dual-modality, fluorescent, PLGA encapsulated bismuth nanoparticles for molecular and cellular fluorescence imaging and computed tomography.Nanoscale · 2014Article
- Functional magnetic nanoparticles for non-viral gene delivery and MR imaging.Pharmaceutical research · 2014Review
- Self-organized MnJournal of materials chemistry. B · 2014Article
- Nonporous Silica Nanoparticles for Nanomedicine Application.Nano today · 2013Article
- Nanoparticle-based systems for T(1)-weighted magnetic resonance imaging contrast agents.International journal of molecular sciences · 2013Review
- Effects of Mesoporous Silica Coating and Post-Synthetic Treatment on the Transverse Relaxivity of Iron Oxide Nanoparticles.Chemistry of materials : a publication of the American Chemical Society · 2013Article
- Mn₃[Co(CN)₆]₂@SiO₂ core-shell nanocubes: novel bimodal contrast agents for MRI and optical imaging.Scientific reports · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
MnO nanoparticles have been tested to engineer a delayed increase in MRI T(1) relaxivity caused by cellular uptake via endocytosis into acidic compartments. Various coatings on core-shell structured MnO nanoparticles were tested for those that had the lowest T(1) relaxivity at pH 7.4, a pH where MnO does not dissolve into Mn(2+) ions. The rate of dissolution and release of Mn(2+) of the different coated MnO particles as well as changes in T(1) relaxivity were measured at pH 5, a pH routinely obtained in the endosomal-lysosomal pathway. Of a number of coatings, silica coated MnO (MnO@SiO(2)) had the lowest relaxivity at pH 7.4 (0.29 mm(-1) sec(-1)). About one third of the MnO dissolved within 20 min and the T(1) relaxivity increased to that of free Mn(2+) (6.10 mm(-1) sec(-1)) after three days at pH 5. MRI of MnO@SiO(2) particles injected into the rat brain showed time-dependent signal changes consistent with the in vitro rates. Thalamocortical tract-tracing could be observed due to the released Mn(2+). Intravenous infusion of MnO@SiO(2) particles showed little enhancement in any tissue except gallbladder. The gallbladder enhancement was interpreted to be due to endocytosis by liver cells and excretion of Mn(2+) ions into the gallbladder. The MnO@SiO(2) core-shell nanoparticles show the best potential for delaying the release of MRI contrast until endocytosis into low pH compartments activate MRI contrast. The delayed enhancement may have benefits for targeting MRI contrast to specific cells and surface receptors that are known to be recycled by endocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.