ReviewClinics in perinatology2012
Anesthesia and analgesia in the NICU.
Review in Clinics in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The analgesic effects of human milk odor in preterm neonates: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- Pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates.The Cochrane database of systematic reviews · 2025Pooled it
- Neonatal Pain, Agitation, and Sedation Scale's use, reliability, and validity: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2020Pooled it
- Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.The Cochrane database of systematic reviews · 2020Pooled it
- Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.The Cochrane database of systematic reviews · 2016Pooled it
- Oral glucose for pain relief during examination for retinopathy of prematurity: a masked randomized clinical trial.Clinics (Sao Paulo, Brazil) · 2013Trial
- Potential Drug-Drug Interactions in Critically Ill Neonates: Association With Clinical Outcomes in a Prospective Cohort.Critical care research and practice · 2026Article
- Role of maternal sound stimulation in the NICU: improving outcomes for newborns and their families.Frontiers in pediatrics · 2026Review
- Dexmedetomidine's effect on neonatal sedation, pain, respiratory status and cardiovascular system.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Observational
- COMFORTneo scale: a reliable and valid instrument to measure prolonged pain in neonates?Journal of perinatology : official journal of the California Perinatal Association · 2023Observational
- Implementing use of sucrose analgesia (non-pharmacological management of neonatal pain) in a standalone private facility level 3 neonatal care unit using point of care quality improvement methodology.BMJ open quality · 2022Article
- The Use of Oral Midazolam to Facilitate the Ophthalmic Examination of Children with Autism and Developmental Disorders.Journal of autism and developmental disorders · 2021Article
- Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model.Pediatric research · 2021Article
- Current paradigms and new perspectives on fetal hypoxia: implications for fetal brain development in late gestation.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- Neonatal Pain: Perceptions and Current Practice.Critical care nursing clinics of North America · 2018Review
- Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics.British journal of clinical pharmacology · 2016Review
- Article
- Integrative Care Therapies and Physiological and Pain-related Outcomes in Hospitalized Infants.Global advances in health and medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Painful procedures in the neonatal intensive care unit are common, undertreated, and lead to adverse consequences. A stepwise approach to treatment should include pain recognition, assessment, and treatment, starting with nonpharmacologic and progressing to pharmacologic methods for increasing pain. The most common nonpharmacologic techniques include nonnutritive sucking with and without sucrose, kangaroo care, swaddling, and massage therapy. Drugs used to treat neonatal pain include the opiates, benzodiazepines, barbiturates, ketamine, propofol, acetaminophen, and local and topical anesthetics. The indications, advantages, and disadvantages of the commonly used analgesic drugs are discussed. Guidance and references for drugs and dosing for specific neonatal procedures are provided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.