ReviewClinics in perinatology2012
Pulmonary vasodilator therapy in the NICU: inhaled nitric oxide, sildenafil, and other pulmonary vasodilating agents.
Review in Clinics in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 97 citations in OpenAlex.
- Aberrant PGC-1α signaling in a lamb model of persistent pulmonary hypertension of the newborn.Pediatric research · 2024Article
- Novel insights into the potential applications of stem cells in pulmonary hypertension therapy.Respiratory research · 2024Review
- Implementation of an Inhaled Nitric Oxide Weaning Protocol and Stewardship in a Level 4 NICU to Decrease Inappropriate Use.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Review
- Approach to the Connection between Meconium Consistency and Adverse Neonatal Outcomes: A Retrospective Clinical Review and Prospective In Vitro Study.Children (Basel, Switzerland) · 2021Article
- Update on the use of sildenafil in neonatal pulmonary hypertension: a narrative review of the history, current administration, and future directions.Translational pediatrics · 2021Review
- Frequent mutation of hypoxia-related genes in persistent pulmonary hypertension of the newborn.Respiratory research · 2020Article
- Prostanoids and their analogues for the treatment of pulmonary hypertension in neonates.The Cochrane database of systematic reviews · 2019Review
- Sildenafil Exposure in the Neonatal Intensive Care Unit.American journal of perinatology · 2019Article
- Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Association between oral sildenafil dosing, predicted exposure, and systemic hypotension in hospitalised infants.Cardiology in the young · 2018Article
- The Fetus Can Teach Us: Oxygen and the Pulmonary Vasculature.Children (Basel, Switzerland) · 2017Review
- Management of Congenital Diaphragmatic Hernia in Newborn - Paradigm Shift and Ethical Issues.Indian journal of pediatrics · 2017Article
- Treprostinil for persistent pulmonary hypertension of the newborn, with early onset sepsis in preterm infant: 2 Case reports.Medicine · 2017Article
- Addressing the challenges of phenotyping pediatric pulmonary vascular disease.Pulmonary circulation · 2017Review
- Lung Circulation.Comprehensive Physiology · 2016Review
- Trends in treatment and in-hospital mortality for neonates with congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy.Pediatric research · 2015Article
- Antenatal use of bosentan and/or sildenafil attenuates pulmonary features in rats with congenital diaphragmatic hernia.World journal of pediatrics : WJP · 2014Article
- Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia.Pediatric allergy, immunology, and pulmonology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The perinatal transition from fetal to extrauterine life requires a dramatic change in the circulatory pattern as the organ of gas exchange switches from the placenta to the lungs. Pulmonary hypertension can occur during early newborn life, and present as early respiratory failure or as a complication of more chronic diseases, such as bronchopulmonary dysplasia. The most effective pharmacotherapeutic strategies for infants with persistent pulmonary hypertension of the newborn are directed at selective reduction of pulmonary vascular resistance. This article discusses currently available therapies for pulmonary hypertension, their biologic rationales, and evidence for their clinical effectiveness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.