ReviewClinics in perinatology2012
Evidence-based use of indomethacin and ibuprofen in the neonatal intensive care unit.
Review in Clinics in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Efficacy and Safety of Paracetamol for Patent Ductus Arteriosus Closure in Preterm Infants: An Updated Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2019Pooled it
- Ketorolac for postoperative pain in children.The Cochrane database of systematic reviews · 2018Pooled it
- Trial
- Acetaminophen versus Ibuprofen for the management of hemodynamically significant patent ductus arteriosus in very low birth weight infants: randomized trial.Jornal de pediatriaTrial
- Nutritional Management for Preterm Infants with Common Comorbidities: A Narrative Review.Nutrients · 2025Review
- Drug-Related Side Effects and Contributing Risk Factors in Children With Congenital Heart Disease: A Cross-Sectional Study.Health science reports · 2025Article
- Response of the ductus arteriosus to acetaminophen or indomethacin in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Ototoxic and nephrotoxic drugs in neonatal intensive care units: results of a Spanish and Italian survey.European journal of pediatrics · 2024Article
- Modeling Neonatal Intraventricular Hemorrhage through Intraventricular Injection of Hemoglobin.Journal of visualized experiments : JoVE · 2022Article
- Late Acetaminophen Therapy for Patent Ductus Arteriosus in the Preterm Neonate.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Article
- Vascular and Neuronal Protection in the Developing Retina: Potential Therapeutic Targets for Retinopathy of Prematurity.International journal of molecular sciences · 2019Review
- Managing Procedural Pain in the Neonate Using an Opioid-sparing Approach.Clinical therapeutics · 2019Review
- Article
- Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment.Seminars in fetal & neonatal medicine · 2018Review
- Neonatal independent predictors of severe NEC.Pediatric surgery international · 2018Article
- Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop.Fluids and barriers of the CNS · 2018Review
- Risk of nonsteroidal anti-inflammatory drug-associated renal dysfunction among neonates diagnosed with patent ductus arteriosus and treated with gentamicin.Journal of perinatology : official journal of the California Perinatal Association · 2017Observational
- Low-Dose Intravenous Paracetamol for Patent Ductus Arteriosus in Indomethacin-Resistant or Contraindicated Preterm Infants: Three Cases Reports.AJP reports · 2017Article
- Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration.Paediatric drugs · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Indomethacin and ibuprofen are potent inhibitors of prostaglandin synthesis. Neonates have been exposed to these compounds for more than 3 decades. Indomethacin is commonly used to prevent intraventricular hemorrhage (IVH), and both drugs are prescribed for the treatment or prevention of patent ductus arteriosus (PDA). This review examines the basis for indomethacin and ibuprofen use in the neonatal intensive care population. Despite the call for restrained use of each drug, the most immature infants are likely to need pharmacologic approaches to reduce high-grade IVH, avoid the need for PDA ligation, and preserve the opportunity for an optimal outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.