ReviewClinics in perinatology2012
Antibiotic use and misuse in the neonatal intensive care unit.
Review in Clinics in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Antibiotic strategies for neonatal sepsis: navigating efficacy and emerging resistance patterns.European journal of pediatrics · 2025Pooled it
- Antibiotic regimens for early-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Antibiotic regimens for late-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children.Paediatrics and international child health · 2018Pooled it
- De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock.The Cochrane database of systematic reviews · 2013Pooled it
- Diagnosis value of the serum amyloid A test in neonatal sepsis: a meta-analysis.BioMed research international · 2013Pooled it
- Trial
- Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.Scientific reports · 2021Trial
- Antibiotic Overuse in Premature Low Birth Weight Infants in a Developing Country.The Pediatric infectious disease journal · 2019Trial
- Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries.Health science reports · 2026Article
- Factors Associated with Antibiotic Initiation After DaBT-Hib-IPV Vaccination in NICU-Hospitalized Preterm Infants: The Role of C-Reactive Protein.Journal of clinical medicine · 2026Article
- A machine learning system enables just-in-time risk-stratified sepsis evaluations in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Antimicrobial resistance to colistin in neonates: epidemiological insights and public health implications in Nigeria - a mini review.Annals of medicine · 2025Review
- ESBL-producingEpidemiology and infection · 2025Observational
- Deciphering dynamic antibiotics-microbiome-metabolome interactions in preterm infants using systems biology.iScience · 2025Article
- Article
- Growth inhibition of common neonatal pathogens differs between bovine lactoferrin products.Journal of medical microbiology · 2025Article
- Current Trends in Antibiotic Therapy and Resistance: A Comparative Study of Various Spectrums.Cureus · 2025Article
- Blood volume collected for cultures in infants with suspected neonatal sepsis.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Point-of-Care Serum Amyloid A as a Diagnostic Marker for Neonatal Sepsis.Indian journal of pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Neonatal sepsis causes significant morbidity and mortality, especially in preterm infants. Clinicians are compelled to treat with empiric antibiotics at the first signs of suspected sepsis. Broad-spectrum antibiotics and prolonged treatment with empiric antibiotics are associated with adverse outcomes. Most common neonatal pathogens are susceptible to narrow-spectrum antibiotics. The choice of antibiotic and duration of empiric treatment are strongly associated with center-based risk factors. Clinicians should treat with short courses of narrow-spectrum antibiotics whenever possible, choosing the antibiotics and treatment duration to balance the risks of potentially untreated sepsis against the adverse effects of treatment in infants with sterile cultures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.